boi brother of ihog [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: boiprovided by FlyBase
Official Full Name: brother of ihogprovided by FlyBase
Primary source: FLYBASE:FBgn0040388
Locus tag: Dmel_CG32796
See related: AllianceGenome:FB:FBgn0040388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Boi; CG13756; CG32796; CG7894; CT23737; CT33235; Dmel\CG32796; EG:BACH59J11.2
Summary: Enables coreceptor activity and hedgehog family protein binding activity. Involved in several processes, including compound eye photoreceptor cell differentiation; maintenance of protein location in extracellular region; and regionalization. Located in cell surface and cytoneme. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to several human genes including BOC (BOC cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3A3-3A3; 1-1 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2444167..2470043, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2338200..2364076, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation.
Title: Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation.
Patched and Ihog activity are mutually required for receptor endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of Ihog/Boi proteins in a stripe of cells at the anterior/posterior compartment boundary of the wing imaginal disc.
Title: Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs.
Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand
Title: Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.
miR-932 can modulate Hh activity by specifically targeting Boi in Drosophila.
Title: Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog.
analysis of balancing between hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
Title: Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.
Shifted (Shf) regulates short-range hedgehog (Hh) signaling through interactions with the receptor complex interference Hh (Ihog) and brother of Ihog (Boi).
Title: The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi.
Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation
Title: Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation.
Ihog and Boi are essential for Hedgehog signaling in Drosophila.
Title: Ihog and Boi are essential for Hedgehog signaling in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables coreceptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables hedgehog family protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cuticle pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of protein location in extracellular region	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of protein location in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: brother of ihog

Names: CG32796-PA; CG32796-PB; CG32796-PE; CG32796-PF; CG32796-PG; boi-PA; boi-PB; boi-PE; boi-PF; boi-PG; brother of iHog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2444167..2470043 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166940.3 → NP_726811.1 brother of ihog, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726811.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95R27, Q9W4Y6

Related

FBpp0070441

Conserved Domains (3) summary

smart00410
Location:249 → 329

IG_like; Immunoglobulin like

cd00063
Location:613 → 700

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:352 → 408

Ig; Immunoglobulin domain
NM_001103398.4 → NP_001096868.3 brother of ihog, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096868.3

Status: REVIEWED

UniProtKB/TrEMBL

A8JUV7, Q95R27

Conserved Domains (3) summary

smart00410
Location:249 → 329

IG_like; Immunoglobulin like

cd00063
Location:613 → 700

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:352 → 408

Ig; Immunoglobulin domain
NM_001201611.2 → NP_001188540.1 brother of ihog, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188540.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95R27, Q9W4Y6

Conserved Domains (3) summary

smart00410
Location:249 → 329

IG_like; Immunoglobulin like

cd00063
Location:613 → 700

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:352 → 408

Ig; Immunoglobulin domain
NM_001201612.2 → NP_001188541.1 brother of ihog, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188541.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95R27, Q9W4Y6

Conserved Domains (3) summary

smart00410
Location:249 → 329

IG_like; Immunoglobulin like

cd00063
Location:613 → 700

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl11960
Location:352 → 408

Ig; Immunoglobulin domain
NM_166941.3 → NP_726812.1 brother of ihog, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726812.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SX52, Q9U1M6, Q9W4Y7

Related

FBpp0070442

Conserved Domains (1) summary

cd00063
Location:162 → 249

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...