Pdfr Pigment-dispersing factor receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pdfrprovided by FlyBase
Official Full Name: Pigment-dispersing factor receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0260753
Locus tag: Dmel_CG13758
See related: AllianceGenome:FB:FBgn0260753
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.157; anon-WO0170980.158; BACR25B3.3; CG13758; DmeCG13758; Dmel\CG13758; EG:BACR25B3.3; gop; han; Han; Pdf R; PDF-R; Pdf-R1; PDF-R1; pdfr; pdfR; PdfR; PDFR; PDFR-1
Summary: Enables neuropeptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; circadian temperature homeostasis; and locomotor rhythm. Located in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including adult brain; adult gnathal ganglion; adult neuromere; adult pacemaker neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in achalasia; cardiovascular system disease; diabetes mellitus (multiple); isolated growth hormone deficiency (multiple); and obesity. Orthologous to several human genes including ADCYAP1R1 (ADCYAP receptor type I); GIPR (gastric inhibitory polypeptide receptor); and GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3A4-3A6; 1-1 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2552206..2578640)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2446239..2472673)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results therefore suggest that the protective action of PACAP against PQ-induced defects in the Drosophila nervous system involves the modulation of PDFR signaling in a small number of interconnected neurons.
Title: Neuroprotective effects of PACAP against paraquat-induced oxidative stress in the Drosophila central nervous system.
Body temperature rhythm (BTR) is fundamental for the maintenance of functions essential for homeostasis, such as generating metabolic energy and sleep. One major unsolved question is how body temperature decreases dramatically during the night. Previously, we demonstrated that a BTR-like mechanism, referred to as temperature preference rhythm (TPR), exists in Drosophila Here, we demonstrate that the diuretic hormone 31 (D
Title: Drosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference.
Drosophila master pacemaker neurons perceive both PDF and glutamate via PDFR and mGluRA G-protein coupled receptors that increase or decrease intracellular cAMP, respectively in response to light stimulus.
Title: Differentially timed extracellular signals synchronize pacemaker neuron clocks.
our study identified the Pigment Dispersing Factor Receptor (PdfR) as a regulator of flight circuit development and as a modulator of acute flight
Title: A genetic RNAi screen for IP₃/Ca²⁺ coupled GPCRs in Drosophila identifies the PdfR as a regulator of insect flight.
we show that PDF-R in pacemakers activates a different adenylate cyclase isoform
Title: E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila.
PDFR activation in LN(v)s shifts the balance of circadian activity from evening to morning, similar to behavioral responses to summer-like environmental conditions
Title: Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila.
PdfR is expressed by the muscles of the excretory system, and induces cAMP increases that underlie the myotropic effects of PDF.
Title: Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila.
PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila
Title: PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila.
Data suggest that small lateral PDF receptor-containing neurons directly target a subset of crucial pacemaker neurons, and that there is autocrine feedback signaling by PDF back to PDF-expressing cells.
Title: PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila.
Using circuit-directed rescue of PDF receptor mutants, data show that PDF targeting of just approximately 30 non-PDF evening circadian neurons is sufficient to drive morning behavior.
Title: The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in circadian behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to paraquat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Pigment-dispersing factor receptor

Names: CG13758-PA; CG13758-PB; CG13758-PC; CG13758-PD; PDF receptor; PDF-receptor; Pdf recep- tor; Pdfr-PA; Pdfr-PB; Pdfr-PC; Pdfr-PD; groom of PDF; groom-of-pdf; pigment dispersing factor receptor; pigment dispersing factor receptor 1; pigment-dispersing factor receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2552206..2578640

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297898.1 → NP_001284827.1 Pigment-dispersing factor receptor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284827.1

Status: REVIEWED

UniProtKB/TrEMBL

D5SHT0

Conserved Domains (2) summary

pfam02793
Location:144 → 203

HRM; Hormone receptor domain

cl21561
Location:237 → 494

7tm_4; Olfactory receptor
NM_001297897.1 → NP_001284826.1 Pigment-dispersing factor receptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284826.1

Status: REVIEWED

UniProtKB/TrEMBL

D5SHT0

Conserved Domains (2) summary

pfam02793
Location:144 → 203

HRM; Hormone receptor domain

cl21561
Location:237 → 494

7tm_4; Olfactory receptor
NM_130651.3 → NP_570007.2 Pigment-dispersing factor receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_570007.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A158RFU8, M9NET6, Q9NEF7, Q9W4Y2, X2JDL2

UniProtKB/TrEMBL

D5SHT0

Conserved Domains (2) summary

pfam02793
Location:144 → 203

HRM; Hormone receptor domain

cl21561
Location:237 → 494

7tm_4; Olfactory receptor
NM_001258572.1 → NP_001245501.1 Pigment-dispersing factor receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245501.1

Status: REVIEWED

UniProtKB/TrEMBL

D5SHT0

Conserved Domains (2) summary

pfam02793
Location:213 → 272

HRM; Hormone receptor domain

cl21561
Location:306 → 563

7tm_4; Olfactory receptor