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AANATL7 Arylalkylamine N-acetyltransferase-like 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31236, updated on 4-Jan-2025

Summary

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Official Symbol
AANATL7provided by FlyBase
Official Full Name
Arylalkylamine N-acetyltransferase-like 7provided by FlyBase
Primary source
FLYBASE:FBgn0040376
Locus tag
Dmel_CG13759
See related
AllianceGenome:FB:FBgn0040376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT19803; CG13759; CT33239; DmAANATL7; Dmel\CG13759; EG:BACR25B3.5
Summary
Predicted to enable aralkylamine N-acetyltransferase activity. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See AANATL7 in Genome Data Viewer
Location:
3A6-3A6; 1-1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2580958..2583823)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2474991..2477856)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Pigment-dispersing factor receptor Neighboring gene Vacuolar H[+] ATPase 36kD subunit 3 Neighboring gene uncharacterized protein Neighboring gene will die slowly Neighboring gene egghead

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine. Dempsey DR, et al. Biochemistry, 2015 Apr 28. PMID 25850002, Free PMC Article
  2. Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2. Dempsey DR, et al. Insect Biochem Mol Biol, 2015 Nov. PMID 26476413, Free PMC Article
  3. Insect Arylalkylamine N-Acyltransferases: Mechanism and Role in Fatty Acid Amide Biosynthesis. O'Flynn BG, et al. Front Mol Biosci, 2018. PMID 30094237, Free PMC Article
  4. The essential Drosophila melanogaster gene wds (will die slowly) codes for a WD-repeat protein with seven repeats. Hollmann M, et al. Mol Genet Genomics, 2002 Dec. PMID 12471440
  5. Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. Amherd R, et al. DNA Cell Biol, 2000 Nov. PMID 11098219

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the kinetic mechanism of AANATL7 identified an ordered sequential mechanism, with acetyl-CoA binding first followed by histamine to generate an AANATL7.acetyl-CoA.histamine ternary complex prior to catalysis.
    Title: Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aralkylamine N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
arylalkylamine N-acetyltransferase-like 7
Names
AANATL7-PA
AANATL7-PB
AANATL7-PC
AANATL7-PD
CG13759-PA
CG13759-PB
CG13759-PC
CG13759-PD
arylalkylamine N-Acetyltransferase like 7
arylalkylamine N-Acetyltransferase-like 7
NP_001188542.1
NP_001188543.1
NP_001188544.1
NP_570009.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2580958..2583823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201613.2 → NP_001188542.1  arylalkylamine N-acetyltransferase-like 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188542.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8X2, Q9NEF5, Q9W4Y1
    Conserved Domains (1) summary
    cl17182
    Location:128 → 187
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  2. NM_001201615.1 → NP_001188544.1  arylalkylamine N-acetyltransferase-like 7, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8X2, Q9NEF5, Q9W4Y1
    Conserved Domains (1) summary
    cl17182
    Location:128 → 187
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  3. NM_130653.3 → NP_570009.2  arylalkylamine N-acetyltransferase-like 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570009.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8X2, Q9NEF5, Q9W4Y1
    Related
    FBpp0070421
    Conserved Domains (1) summary
    cl17182
    Location:128 → 187
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  4. NM_001201614.1 → NP_001188543.1  arylalkylamine N-acetyltransferase-like 7, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8X2, Q9NEF5, Q9W4Y1
    Conserved Domains (1) summary
    cl17182
    Location:128 → 187
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T8X2 Q8T8X2
Q9W4Y1 Q9W4Y1

Gene LinkOut

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