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Nt5c3a 5'-nucleotidase, cytosolic IIIA [ Rattus norvegicus (Norway rat) ]

Gene ID: 312373, updated on 27-Nov-2024

Summary

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Official Symbol
Nt5c3aprovided by RGD
Official Full Name
5'-nucleotidase, cytosolic IIIAprovided by RGD
Primary source
RGD:1312013
See related
EnsemblRapid:ENSRNOG00000005981 AllianceGenome:RGD:1312013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nt5c3
Summary
Enables 5'-nucleotidase activity. Involved in adenosine metabolic process. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrion; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human NT5C3A (5'-nucleotidase, cytosolic IIIA). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 82.1), Spleen (RPKM 79.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nt5c3a in Genome Data Viewer
Location:
4q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (87491828..87534838, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (86161642..86204656, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (87238325..87281234, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 2 Neighboring gene FKBP prolyl isomerase 9 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 32 Neighboring gene vomeronasal 1 receptor 65

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human erythrocyte pyrimidine 5'-nucleotidase, PN-I. Amici A, et al. Arch Biochem Biophys, 2002 Jan 15. PMID 11795870
  2. Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon. Amici A, et al. Blood, 2000 Aug 15. PMID 10942414
  3. Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides. Amici A, et al. FEBS Lett, 1997 Dec 15. PMID 9428647
  4. Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions. Rich SA, et al. J Biol Chem, 1996 Jan 12. PMID 8557639
  5. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, et al. J Neurochem, 2003 Apr. PMID 12675911

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in adenosine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic 5'-nucleotidase 3A
Names
5'-nucleotidase, cytosolic III
cytosolic 5'-nucleotidase 3
NP_001101332.1
NP_001385770.1
XP_006236612.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107862.2 → NP_001101332.1  cytosolic 5'-nucleotidase 3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K097, A6K122, B2GUX5, F7ESB1
    Related
    ENSRNOP00000055497.2, ENSRNOT00000058703.4
    Conserved Domains (1) summary
    cl21460
    Location:16 → 295
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001398841.1 → NP_001385770.1  cytosolic 5'-nucleotidase 3A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AHB0, A6K120
    Related
    ENSRNOP00000093312.1, ENSRNOT00000097799.2
    Conserved Domains (1) summary
    cd07504
    Location:59 → 331
    HAD_5NT; haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to human cytosolic IIIA and IIIB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    87491828..87534838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236550.5 → XP_006236612.1  cytosolic 5'-nucleotidase 3A isoform X1

    UniProtKB/TrEMBL
    A0A0G2K097, A6K122, B2GUX5, F7ESB1
    Conserved Domains (1) summary
    cl21460
    Location:16 → 295
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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