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Tia1 TIA1 cytotoxic granule-associated RNA binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 312510, updated on 9-Dec-2024

Summary

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Official Symbol
Tia1provided by RGD
Official Full Name
TIA1 cytotoxic granule-associated RNA binding proteinprovided by RGD
Primary source
RGD:1305742
See related
EnsemblRapid:ENSRNOG00000016813 AllianceGenome:RGD:1305742
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in positive regulation of epithelial cell apoptotic process. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 172.0), Brain (RPKM 95.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tia1 in Genome Data Viewer
Location:
4q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120410180..120440676)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118852765..118883252)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118207845..118238246)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase 1 Neighboring gene transfer RNA glycine (anticodon CCC) 4 Neighboring gene similar to human chromosome 2 open reading frame 42 Neighboring gene uncharacterized LOC134486603 Neighboring gene uncharacterized LOC134486604

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules. Kayali F, et al. Neuroscience, 2005. PMID 16055272
  2. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Zou T, et al. Am J Physiol Cell Physiol, 2012 Jul 1. PMID 22555848, Free PMC Article
  3. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Förch P, et al. Mol Cell, 2000 Nov. PMID 11106748
  4. Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins. Zhang T, et al. J Cell Sci, 2005 Dec 1. PMID 16278295
  5. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. Piecyk M, et al. EMBO J, 2000 Aug 1. PMID 10921895, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIAR regulates the relative expression of TIA-1 isoforms.
    Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytotoxic granule associated RNA binding protein TIA1
Names
cytotoxic granule-associated RNA binding protein 1
nucleolysin TIA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012096.1 → NP_001012096.1  cytotoxic granule associated RNA binding protein TIA1

    See identical proteins and their annotated locations for NP_001012096.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087064
    UniProtKB/TrEMBL
    F7FKD5, Q5PQR7
    Related
    ENSRNOP00000094527.1, ENSRNOT00000107832.2
    Conserved Domains (4) summary
    cd12618
    Location:94 → 173
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:203 → 276
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6 → 269
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:8 → 81
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    120410180..120440676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236828.4 → XP_006236890.1  cytotoxic granule associated RNA binding protein TIA1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AKZ8
    Related
    ENSRNOP00000096950.2, ENSRNOT00000110929.2
    Conserved Domains (4) summary
    cd12618
    Location:106 → 185
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12620
    Location:215 → 287
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    TIGR01661
    Location:6 → 281
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:8 → 82
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_006236830.5 → XP_006236892.1  cytotoxic granule associated RNA binding protein TIA1 isoform X7

    UniProtKB/TrEMBL
    F7FKD5
    Related
    ENSRNOP00000023102.5, ENSRNOT00000023103.6
    Conserved Domains (4) summary
    cd12618
    Location:95 → 174
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:204 → 277
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6 → 270
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:8 → 82
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_063286065.1 → XP_063142135.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AKZ8

  4. XM_063286067.1 → XP_063142137.1  cytotoxic granule associated RNA binding protein TIA1 isoform X4

    UniProtKB/TrEMBL
    F7FKD5

  5. XM_039107613.2 → XP_038963541.1  cytotoxic granule associated RNA binding protein TIA1 isoform X10

    UniProtKB/TrEMBL
    A0A8I6ASW3
    Conserved Domains (1) summary
    cl17169
    Location:8 → 82
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006236829.5 → XP_006236891.1  cytotoxic granule associated RNA binding protein TIA1 isoform X5

    See identical proteins and their annotated locations for XP_006236891.1

    UniProtKB/TrEMBL
    A0A8I6AKZ8, A6IAW7
    Conserved Domains (4) summary
    cd12618
    Location:105 → 184
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12620
    Location:214 → 286
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    TIGR01661
    Location:6 → 280
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:8 → 81
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_063286066.1 → XP_063142136.1  cytotoxic granule associated RNA binding protein TIA1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AKZ8

  8. XM_063286068.1 → XP_063142138.1  cytotoxic granule associated RNA binding protein TIA1 isoform X6

    UniProtKB/TrEMBL
    F7FKD5

  9. XM_063286069.1 → XP_063142139.1  cytotoxic granule associated RNA binding protein TIA1 isoform X8

  10. XM_063286071.1 → XP_063142141.1  cytotoxic granule associated RNA binding protein TIA1 isoform X9

  11. XM_063286070.1 → XP_063142140.1  cytotoxic granule associated RNA binding protein TIA1 isoform X9

  12. XM_063286072.1 → XP_063142142.1  cytotoxic granule associated RNA binding protein TIA1 isoform X9

RNA

  1. XR_005503216.2 RNA Sequence

  2. XR_005503217.2 RNA Sequence

  3. XR_005503219.2 RNA Sequence

  4. XR_005503220.2 RNA Sequence

  5. XR_005503221.2 RNA Sequence

  6. XR_005503218.2 RNA Sequence

    Related
    ENSRNOT00000112790.2
Nucleotide Protein Strain
Heading Accession and Version

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