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eIF2Bbeta eukaryotic translation initiation factor 2B subunit beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31256, updated on 9-Dec-2024

Summary

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Official Symbol
eIF2Bbetaprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 2B subunit betaprovided by FlyBase
Primary source
FLYBASE:FBgn0024996
Locus tag
Dmel_CG2677
See related
AllianceGenome:FB:FBgn0024996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2677; DMC100G10.3; Dmel\CG2677; EG:100G10.3; EIF2b; eIF2B-b; eIF2B-beta; eIF2beta
Summary
Predicted to enable translation initiation factor activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in cellular response to hypoxia. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See eIF2Bbeta in Genome Data Viewer
Location:
3B2-3B2; 1-1.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2704571..2706217)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2598604..2600250)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene L(3)mbt interactor in ovarian somatic cells Neighboring gene UDP-galactose transporter Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
  2. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article
  3. Quantitative proteomic analysis of Parkin substrates in Drosophila neurons. Martinez A, et al. Mol Neurodegener, 2017 Apr 11. PMID 28399880, Free PMC Article
  4. Identification of ALK in Thinness. Orthofer M, et al. Cell, 2020 Jun 11. PMID 32442405
  5. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2B subunit beta
Names
CG2677-PA
eIF2B-beta
eIF2Bbeta-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2704571..2706217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130664.4 → NP_570020.1  eukaryotic translation initiation factor 2B subunit beta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570020.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76863
    Related
    FBpp0070457
    Conserved Domains (2) summary
    cl00348
    Location:8 → 345
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:21 → 334
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76863 O76863

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