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fs(1)Ya female sterile (1) Young arrest [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31263, updated on 9-Dec-2024

Summary

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Official Symbol
fs(1)Yaprovided by FlyBase
Official Full Name
female sterile (1) Young arrestprovided by FlyBase
Primary source
FLYBASE:FBgn0000927
Locus tag
Dmel_CG2707
See related
AllianceGenome:FB:FBgn0000927
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2707; Dmel\CG2707; EG:95B7.4; fs(1)73; fs(1)M12; fs(1)Y2; fs(1)Y[a]; Ya; YA
Summary
Involved in several processes, including DNA replication; chromosome condensation; and pronuclear fusion. Located in cytoplasm; nuclear envelope; and nuclear lamina. Is expressed in several structures, including female germline cell; ovary; pronucleus; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See fs(1)Ya in Genome Data Viewer
Location:
3B3-3B3; 1-1.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2724286..2726577)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2618319..2620610)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene female sterile (1) Yb Neighboring gene vilya Neighboring gene deformed wings

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains. Yu J, et al. Mol Biol Cell, 2002 Feb. PMID 11854412, Free PMC Article
  2. The developmentally regulated Drosophila embryonic nuclear lamina protein 'Young Arrest' (fs(1)Ya) is capable of associating with chromatin. Lopez JM, et al. J Cell Sci, 1997 Mar. PMID 9092946
  3. The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei. Lopez JM, et al. Dev Biol, 1994 May. PMID 8174776
  4. Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster. Liu J, et al. Mol Cell Biol, 1998 Jan. PMID 9418866, Free PMC Article
  5. A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope. Mani SS, et al. J Cell Sci, 2003 May 15. PMID 12679383

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest YA function is needed at a control point, following meiosis II and the initiation of the first postmeiotic S phase, which is sensitive to the chromatin condensation state of the haploid meiotic products.
    Title: YA is needed for proper nuclear organization to transition between meiosis and mitosis in Drosophila.
  2. P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embryo cytoplasms
    Title: Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location.
  3. the hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope
    Title: A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pronuclear fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nuclear lamina IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
female sterile (1) young arrest
Names
CG2707-PA
fs(1)Ya-PA
young arrest

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2724286..2726577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058145.4 → NP_477493.2  female sterile (1) young arrest [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477493.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25028, Q8T057, Q9W4W0, Q9W4W1
    Related
    FBpp0070463
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25028.4 P25028

Gene LinkOut

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