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vilya vilya [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31264, updated on 9-Dec-2024

Summary

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Official Symbol
vilyaprovided by FlyBase
Official Full Name
vilyaprovided by FlyBase
Primary source
FLYBASE:FBgn0283545
Locus tag
Dmel_CG2709
See related
AllianceGenome:FB:FBgn0283545
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2709; Dmel\CG2709; EG:95B7.5; mei-826; Vilya
Summary
Predicted to enable SUMO transferase activity. Involved in female meiotic nuclear division and positive regulation of meiotic DNA double-strand break formation. Located in central element; recombination nodule; and site of double-strand break. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See vilya in Genome Data Viewer
Location:
3B3-3B3; 1-1.5 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2726678..2727568)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2620740..2621522)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) Yb Neighboring gene female sterile (1) Young arrest Neighboring gene deformed wings Neighboring gene tiny tim 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance. Lake CM, et al. Proc Natl Acad Sci U S A, 2024 Sep 3. PMID 39190345, Free PMC Article
  2. A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure. Gershoni M, et al. HGG Adv, 2023 Jul 13. PMID 37124137, Free PMC Article
  3. X chromosome and autosomal recombination are differentially sensitive to disruptions in SC maintenance. Billmyre KK, et al. Proc Natl Acad Sci U S A, 2019 Oct 22. PMID 31570610, Free PMC Article
  4. Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity. Zhaunova L, et al. PLoS Genet, 2016 Aug. PMID 27494704, Free PMC Article
  5. Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster. Lake CM, et al. PLoS Genet, 2019 Jan. PMID 30615609, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SUMO transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of meiotic DNA double-strand break formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in central element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recombination nodule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptonemal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vilya
Names
CG2709-PA
meiotic 826
vilya-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2726678..2727568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130670.2 → NP_570026.1  vilya [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570026.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76908
    Related
    FBpp0070464
    Conserved Domains (2) summary
    pfam11500
    Location:112 → 170
    Cut12; Spindle pole body formation-associated protein
    pfam14634
    Location:20 → 70
    zf-RING_5; zinc-RING finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76908.1 O76908

Gene LinkOut

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