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Marchf8 membrane associated ring-CH-type finger 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312656, updated on 27-Nov-2024

Summary

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Official Symbol
Marchf8provided by RGD
Official Full Name
membrane associated ring-CH-type finger 8provided by RGD
Primary source
RGD:1309339
See related
EnsemblRapid:ENSRNOG00000012297 AllianceGenome:RGD:1309339
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mir; March8
Summary
Predicted to enable MHC class II protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including antigen processing and presentation of peptide antigen via MHC class II; negative regulation of MHC class II biosynthetic process; and protein polyubiquitination. Predicted to be located in endosome. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF8 (membrane associated ring-CH-type finger 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 204.9), Liver (RPKM 163.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Marchf8 in Genome Data Viewer
Location:
4q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (151086076..151203205)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149415642..149530771)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (148285467..148398148)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 2C Neighboring gene ribosomal protein L9, pseudogene 19 Neighboring gene zinc finger AN1-type containing 4 Neighboring gene ribosomal protein L23A like 6 Neighboring gene arachidonate 5-lipoxygenase Neighboring gene transfer RNA proline (anticodon GGG) 3 Neighboring gene olfactory receptor family 13 subfamily A member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of MHC class II expression and immune responses by c-MIR. Ohmura-Hoshino M, et al. J Immunol, 2006 Jul 1. PMID 16785530
  2. The HLA-DRalpha chain is modified by polyubiquitination. Lapaque N, et al. J Biol Chem, 2009 Mar 13. PMID 19117940, Free PMC Article
  3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MHC class II protein binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF8
Names
E3 ubiquitin-protein ligase MARCH8
c-mir, cellular modulator of immune recognition
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
NP_001101352.1
NP_001388595.1
NP_001388603.1
XP_017448134.1
XP_017448136.1
XP_038963572.1
XP_038963573.1
XP_063142173.1
XP_063142174.1
XP_063142175.1
XP_063142176.1
XP_063142177.1
XP_063142178.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107882.2 → NP_001101352.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

    See identical proteins and their annotated locations for NP_001101352.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IL15, D3ZG81
    Related
    ENSRNOP00000017294.2, ENSRNOT00000017294.6
    Conserved Domains (1) summary
    cd16698
    Location:75 → 126
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

  2. NM_001401666.1 → NP_001388595.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IL15, D3ZG81

  3. NM_001401674.1 → NP_001388603.1  E3 ubiquitin-protein ligase MARCHF8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0U1RS36
    Related
    ENSRNOP00000075920.2, ENSRNOT00000092294.3
    Conserved Domains (1) summary
    cd16807
    Location:352 → 414
    RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    151086076..151203205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107644.2 → XP_038963572.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RS36
    Conserved Domains (1) summary
    cd16807
    Location:352 → 414
    RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

  2. XM_063286106.1 → XP_063142176.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

    UniProtKB/TrEMBL
    A6IL15, D3ZG81

  3. XM_063286103.1 → XP_063142173.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RS36

  4. XM_017592647.3 → XP_017448136.1  E3 ubiquitin-protein ligase MARCHF8 isoform X2

    Conserved Domains (1) summary
    cd16698
    Location:318 → 369
    RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

  5. XM_039107645.2 → XP_038963573.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RS36
    Conserved Domains (1) summary
    cd16807
    Location:352 → 414
    RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

  6. XM_063286105.1 → XP_063142175.1  E3 ubiquitin-protein ligase MARCHF8 isoform X2

    Related
    ENSRNOP00000105630.1, ENSRNOT00000167151.1

  7. XM_063286104.1 → XP_063142174.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RS36

  8. XM_063286108.1 → XP_063142178.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

    UniProtKB/TrEMBL
    A6IL15, D3ZG81

  9. XM_017592645.3 → XP_017448134.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RS36
    Conserved Domains (1) summary
    cd16807
    Location:352 → 414
    RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

  10. XM_063286107.1 → XP_063142177.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

    UniProtKB/TrEMBL
    A6IL15, D3ZG81
Nucleotide Protein Strain
Heading Accession and Version

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