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Etnk1 ethanolamine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312828, updated on 27-Nov-2024

Summary

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Official Symbol
Etnk1provided by RGD
Official Full Name
ethanolamine kinase 1provided by RGD
Primary source
RGD:1308204
See related
EnsemblRapid:ENSRNOG00000014856 AllianceGenome:RGD:1308204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ethanolamine kinase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human ETNK1 (ethanolamine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 799.1), Thymus (RPKM 387.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Etnk1 in Genome Data Viewer
Location:
4q44
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (177857001..177901278)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (176126056..176170325)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (177402904..177447047)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486862 Neighboring gene C2 calcium-dependent domain containing 5 Neighboring gene uncharacterized LOC134486689 Neighboring gene uncharacterized LOC102553594

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. Lykidis A, et al. J Biol Chem, 2001 Jan 19. PMID 11044454
  2. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Bailey MJ, et al. J Biol Chem, 2009 Mar 20. PMID 19103603, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ethanolamine kinase 1
NP_001101364.1
XP_038963633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107894.2 → NP_001101364.1  ethanolamine kinase 1

    See identical proteins and their annotated locations for NP_001101364.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AFB2, A6IMX1, D3ZXB8
    Related
    ENSRNOP00000102359.1, ENSRNOT00000163938.1
    Conserved Domains (1) summary
    cd05157
    Location:49 → 351
    ETNK_euk; Euykaryotic Ethanolamine kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    177857001..177901278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107705.2 → XP_038963633.1  ethanolamine kinase 1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:49 → 234
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_005503240.2 RNA Sequence

  2. XR_010065649.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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