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kirre kin of irre [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31292, updated on 9-Dec-2024

Summary

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Official Symbol
kirreprovided by FlyBase
Official Full Name
kin of irreprovided by FlyBase
Primary source
FLYBASE:FBgn0028369
Locus tag
Dmel_CG3653
See related
AllianceGenome:FB:FBgn0028369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3653; CT12279; Dmel\CG3653; dNeph; duf; Duf; DUF; duf/kirre; Duf/Kirre; DUF/KIRRE; EG:163A10.1; Kirre; Neph1; RH09239
Summary
Enables cell adhesion molecule binding activity and coreceptor activity. Involved in several processes, including garland nephrocyte differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in apical plasma membrane and nephrocyte diaphragm. Is active in presynaptic membrane. Colocalizes with cell-cell junction. Is expressed in several structures, including head; medulla layer; muscle cell; myoblast; and nephrocyte. Used to study kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1) and KIRREL2 (kirre like nephrin family adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See kirre in Genome Data Viewer
Location:
3B4-3C7; 1-2 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2740384..3134532)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2634417..3028565)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43494 Neighboring gene uncharacterized protein Neighboring gene tiny tim 50 Neighboring gene Syntaxin 4 Neighboring gene cramped Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene white Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene roughest Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Notch

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The irre cell recognition module (IRM) protein Kirre is required to form the reciprocal synaptic network of L4 neurons in the Drosophila lamina. Lüthy K, et al. J Neurogenet, 2014 Sep-Dec. PMID 24697410
  2. The decompact state of interchromomeric chromatin from the 3C6/C7 region of Drosophila melanogaster is determined by short DNA sequence. Andreyenkov OV, et al. Dokl Biochem Biophys, 2010 Mar-Apr. PMID 20514862
  3. Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research. Hagmann H, et al. Front Pediatr, 2018. PMID 30057894, Free PMC Article
  4. [Chromatin decompaction in the interbands of Drosophila polytene chromosomes does not correlate with high transcription level]. Kvon EZ, et al. Genetika, 2011 Jun. PMID 21866857
  5. rst transcriptional activity influences kirre mRNA concentration in the Drosophila pupal retina during the final steps of ommatidial patterning. Machado MC, et al. PLoS One, 2011. PMID 21857931, Free PMC Article

See all (237) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results uncover a significant but hitherto uncharacterized involvement of IRM components Hbs, Kirre, and specially Rst in ovarian development
    Title: Expression of Hbs, Kirre, and Rst during Drosophila ovarian development.
  2. the roles of Rst, Hbs, Kirre and SNS in the spacing of bristles of the anterior wing margin, are explored.
    Title: The Cell Adhesion Molecules Roughest, Hibris, Kin of Irre and Sticks and Stones Are Required for Long Range Spacing of the Drosophila Wing Disc Sensory Sensilla.
  3. removing Kirre protein specifically disrupts the functional L4 synaptic network in the Drosophila lamina.
    Title: The irre cell recognition module (IRM) protein Kirre is required to form the reciprocal synaptic network of L4 neurons in the Drosophila lamina.
  4. Dumbfounded/Neph1, a key diaphragm constituent, is a target of the Src kinase Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 tyrosine phosphorylation.
    Title: Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies.
  5. Analysis of a cytoplasmic motif present in Kirre and IrreC/Rst revealed a functionally required, conserved 12 AA motif (KIN1 motif).
    Title: Functional study of mammalian Neph proteins in Drosophila melanogaster.
  6. Dumbfounded and Sticks and Stones are expressed in the genital imaginal disc and in the muscle sheath of the testes during muscle differentiation.
    Title: Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster.
  7. Findings suggest a general mechanism by which rst and kirre expression could be fine tuned to optimize their redundant roles during development.
    Title: rst transcriptional activity influences kirre mRNA concentration in the Drosophila pupal retina during the final steps of ommatidial patterning.
  8. Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
    Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
  9. analysis of the spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre
    Title: The complex spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre.
  10. Kirre and Sns are co-expressed within binucleate garland cell nephrocytes that contribute to detoxification of hemolymph by uptake of molecules through a slit diaphragm-like nephrocyte diaphragm into labyrinthine channels that are sites of endocytosis.
    Title: Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 3075689-3080937 mobile_element_type = transposon:Transpac{}32

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables coreceptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaeta morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in filtration diaphragm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in garland nephrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval visceral muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nephrocyte diaphragm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nephrocyte filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of striated muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of striated muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nephrocyte diaphragm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
kin of irre
Names
CG3653-PA
CG3653-PB
CG3653-PC
CG3653-PD
CG3653-PE
CG3653-PF
CG3653-PG
Dumbfounded/Kirre
Kin of irre
Kin of irregular-chiasm-C
Kin-of-irre
dumbfounded
kin of irreC
kin-of-irreC
kirre
kirre-PA
kirre-PB
kirre-PC
kirre-PD
kirre-PE
kirre-PF
kirre-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2740384..3134532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258578.1 → NP_001245507.1  kin of irre, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245507.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain

  2. NM_001258579.3 → NP_001245508.1  kin of irre, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain

  3. NM_080320.4 → NP_525059.2  kin of irre, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525059.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Related
    FBpp0070534
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain

  4. NM_001272267.1 → NP_001259196.1  kin of irre, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain

  5. NM_001258576.1 → NP_001245505.1  kin of irre, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245505.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain

  6. NM_001258577.1 → NP_001245506.1  kin of irre, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245506.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain

  7. NM_166958.2 → NP_726844.1  kin of irre, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N9Y9, Q9NCP3, Q9W4T9
    Related
    FBpp0070535
    Conserved Domains (6) summary
    smart00408
    Location:396 → 446
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:88 → 182
    IG_like; Immunoglobulin like
    pfam07679
    Location:382 → 462
    I-set; Immunoglobulin I-set domain
    pfam08205
    Location:189 → 279
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13895
    Location:307 → 379
    Ig_2; Immunoglobulin domain
    cl11960
    Location:466 → 561
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97174 O97174
Q8MSN7 Q8MSN7
Q9N9Y9 Q9N9Y9
Q9W4T9 Q9W4T9

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