N - Notch

Enables several functions, including WW domain binding activity; histone acetyltransferase binding activity; and transcription coactivator activity. Involved in several processes, including neurogenesis; regionalization; and regulation of cell development. Located in several cellular components, including adherens junction; apical plasma membrane; and cytoplasmic vesicle. Part of CSL-Notch-Mastermind transcription factor complex. Colocalizes with late endosome and lysosome. Is expressed in several structures, including anterior-posterior subdivision of organism; compartment boundary; epithelial cell; germline cell; and larval optic anlage. Used to study alcohol use disorder and cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; Alagille syndrome; CADASIL 1; Hajdu-Cheney syndrome; and adult T-cell leukemia/lymphoma. Orthologous to several human genes including NOTCH1 (notch receptor 1) and NOTCH2 (notch receptor 2). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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