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Asph aspartate-beta-hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 312981, updated on 27-Nov-2024

Summary

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Symbol
Asphprovided by RGD
Full Name
aspartate-beta-hydroxylaseprovided by RGD
Primary source
RGD:1312000
See related
EnsemblRapid:ENSRNOG00000007445 AllianceGenome:RGD:1312000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and peptidyl-aspartic acid 3-dioxygenase activity. Involved in regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum subcompartment; myofibril; and plasma membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cholangiocarcinoma. Orthologous to human ASPH (aspartate beta-hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 178.5), Heart (RPKM 126.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asph in Genome Data Viewer
Location:
5q13
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (27398933..27611519, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (22601581..22814107, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (22577680..22799333, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene clavesin 1 Neighboring gene uncharacterized LOC134486920 Neighboring gene uncharacterized LOC120102822 Neighboring gene uncharacterized LOC120102823 Neighboring gene uncharacterized LOC134486921 Neighboring gene uncharacterized LOC103692300 Neighboring gene growth differentiation factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunization with aspartate-β-hydroxylase-loaded dendritic cells produces antitumor effects in a rat model of intrahepatic cholangiocarcinoma. Noda T, et al. Hepatology, 2012 Jan. PMID 21898484, Free PMC Article
  2. Junctin is a prominent regulator of contractility in cardiomyocytes. Fan GC, et al. Biochem Biophys Res Commun, 2007 Jan 19. PMID 17150191, Free PMC Article
  3. Myocyte enhancer factor 2 activates promoter sequences of the human AbetaH-J-J locus, encoding aspartyl-beta-hydroxylase, junctin, and junctate. Feriotto G, et al. Mol Cell Biol, 2005 Apr. PMID 15798210, Free PMC Article
  4. Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. Treves S, et al. J Cell Biol, 2004 Aug 16. PMID 15302852, Free PMC Article
  5. On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Gergs U, et al. Am J Physiol Heart Circ Physiol, 2007 Jul. PMID 17400717

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-aspartic acid 3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-aspartic acid hydroxylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in junctional sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aspartyl/asparaginyl beta-hydroxylase
Names
junctate
junctin
NP_001091709.1
NP_001388868.1
XP_006237921.1
XP_006237922.1
XP_006237923.1
XP_006237924.1
XP_006237925.1
XP_008761797.1
XP_038965701.1
XP_063143596.1
XP_063143597.1
XP_063143598.1
XP_063143599.1
XP_063143600.1
XP_063143601.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098239.1 → NP_001091709.1  aspartyl/asparaginyl beta-hydroxylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC085901
    UniProtKB/TrEMBL
    Q5U2Q8
    Conserved Domains (1) summary
    pfam05279
    Location:25 → 187
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  2. NM_001401939.1 → NP_001388868.1  aspartyl/asparaginyl beta-hydroxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A096MKE0
    Related
    ENSRNOP00000068479.1, ENSRNOT00000076426.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    27398933..27611519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237861.5 → XP_006237923.1  aspartyl/asparaginyl beta-hydroxylase isoform X3

    See identical proteins and their annotated locations for XP_006237923.1

    UniProtKB/TrEMBL
    A0A096MJA9, A0A8I5ZX44
    Related
    ENSRNOP00000082407.2, ENSRNOT00000118158.2
    Conserved Domains (6) summary
    PHA02664
    Location:130 → 224
    PHA02664; hypothetical protein; Provisional
    pfam05279
    Location:61 → 264
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:399 → 423
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:532 → 685
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:286 → 325
    TPR_14; Tetratricopeptide repeat
    pfam13432
    Location:286 → 356
    TPR_16; Tetratricopeptide repeat

  2. XM_006237862.5 → XP_006237924.1  aspartyl/asparaginyl beta-hydroxylase isoform X4

    See identical proteins and their annotated locations for XP_006237924.1

    UniProtKB/TrEMBL
    A0A0G2K2B5
    Conserved Domains (6) summary
    PHA02664
    Location:109 → 203
    PHA02664; hypothetical protein; Provisional
    pfam05279
    Location:25 → 243
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:378 → 402
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:511 → 664
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:265 → 304
    TPR_14; Tetratricopeptide repeat
    pfam13432
    Location:265 → 335
    TPR_16; Tetratricopeptide repeat

  3. XM_006237859.5 → XP_006237921.1  aspartyl/asparaginyl beta-hydroxylase isoform X1

    See identical proteins and their annotated locations for XP_006237921.1

    UniProtKB/TrEMBL
    A0A0G2K2B5
    Conserved Domains (6) summary
    PHA02664
    Location:92 → 241
    PHA02664; hypothetical protein; Provisional
    pfam05279
    Location:25 → 281
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:416 → 440
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:549 → 702
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:303 → 342
    TPR_14; Tetratricopeptide repeat
    pfam13432
    Location:303 → 373
    TPR_16; Tetratricopeptide repeat

  4. XM_063287526.1 → XP_063143596.1  aspartyl/asparaginyl beta-hydroxylase isoform X5

  5. XM_006237860.5 → XP_006237922.1  aspartyl/asparaginyl beta-hydroxylase isoform X2

    See identical proteins and their annotated locations for XP_006237922.1

    UniProtKB/TrEMBL
    A0A0G2K2B5
    Related
    ENSRNOP00000072176.3, ENSRNOT00000083779.3
    Conserved Domains (6) summary
    PHA02664
    Location:77 → 226
    PHA02664; hypothetical protein; Provisional
    pfam05279
    Location:25 → 266
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
    sd00006
    Location:401 → 425
    TPR; TPR repeat [structural motif]
    pfam05118
    Location:534 → 687
    Asp_Arg_Hydrox; Aspartyl/Asparaginyl beta-hydroxylase
    pfam13428
    Location:288 → 327
    TPR_14; Tetratricopeptide repeat
    pfam13432
    Location:288 → 358
    TPR_16; Tetratricopeptide repeat

  6. XM_063287527.1 → XP_063143597.1  aspartyl/asparaginyl beta-hydroxylase isoform X6

  7. XM_063287529.1 → XP_063143599.1  aspartyl/asparaginyl beta-hydroxylase isoform X9

    UniProtKB/TrEMBL
    A0A096MK70

  8. XM_039109773.2 → XP_038965701.1  aspartyl/asparaginyl beta-hydroxylase isoform X7

    Conserved Domains (1) summary
    pfam05279
    Location:61 → 377
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  9. XM_063287528.1 → XP_063143598.1  aspartyl/asparaginyl beta-hydroxylase isoform X8

  10. XM_006237863.5 → XP_006237925.1  aspartyl/asparaginyl beta-hydroxylase isoform X10

    See identical proteins and their annotated locations for XP_006237925.1

    Conserved Domains (1) summary
    pfam05279
    Location:61 → 223
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  11. XM_063287530.1 → XP_063143600.1  aspartyl/asparaginyl beta-hydroxylase isoform X11

  12. XM_008763575.4 → XP_008761797.1  aspartyl/asparaginyl beta-hydroxylase isoform X12

    See identical proteins and their annotated locations for XP_008761797.1

    UniProtKB/TrEMBL
    A0A8I5ZX27
    Conserved Domains (1) summary
    pfam05279
    Location:61 → 153
    Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

  13. XM_063287531.1 → XP_063143601.1  aspartyl/asparaginyl beta-hydroxylase isoform X13

RNA

  1. XR_010066377.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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