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Adgrb2 adhesion G protein-coupled receptor B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313058, updated on 14-Nov-2024

Summary

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Official Symbol
Adgrb2provided by RGD
Official Full Name
adhesion G protein-coupled receptor B2provided by RGD
Primary source
RGD:1309431
See related
EnsemblRapid:ENSRNOG00000014375 AllianceGenome:RGD:1309431
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bai2
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; calcineurin-NFAT signaling cascade; and peripheral nervous system development. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be active in glutamatergic synapse and plasma membrane. Orthologous to human ADGRB2 (adhesion G protein-coupled receptor B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 160.2), Muscle (RPKM 67.6) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adgrb2 in Genome Data Viewer
Location:
5q36
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (147581573..147646726)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (142299190..142362540)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (148168530..148231587)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486996 Neighboring gene SPOC domain containing 1 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC120102987 Neighboring gene penta-EF hand domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Purcell RH, et al. Hum Mutat, 2017 Dec. PMID 28891236, Free PMC Article
  2. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. Kee HJ, et al. J Cereb Blood Flow Metab, 2002 Sep. PMID 12218411
  3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor B2
Names
brain-specific angiogenesis inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107914.1 → NP_001101384.1  adhesion G protein-coupled receptor B2 precursor

    See identical proteins and their annotated locations for NP_001101384.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A0A8I6GF79, A6ISM9, D3ZN99
    Related
    ENSRNOP00000060321.1, ENSRNOT00000064948.3
    Conserved Domains (5) summary
    smart00303
    Location:863 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:521 → 585
    HormR; Domain present in hormone receptors
    smart00209
    Location:357 → 407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:922 → 1191
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:605 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    147581573..147646726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238935.5 → XP_006238997.1  adhesion G protein-coupled receptor B2 isoform X2

    See identical proteins and their annotated locations for XP_006238997.1

    UniProtKB/TrEMBL
    A0A8I6GF79, A6ISM9, D3ZN99
    Conserved Domains (5) summary
    smart00303
    Location:863 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:521 → 585
    HormR; Domain present in hormone receptors
    smart00209
    Location:357 → 407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:922 → 1191
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:605 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  2. XM_006238934.3 → XP_006238996.1  adhesion G protein-coupled receptor B2 isoform X2

    See identical proteins and their annotated locations for XP_006238996.1

    UniProtKB/TrEMBL
    A0A8I6GF79, A6ISM9, D3ZN99
    Conserved Domains (5) summary
    smart00303
    Location:863 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:521 → 585
    HormR; Domain present in hormone receptors
    smart00209
    Location:357 → 407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:922 → 1191
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:605 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. XM_017593334.1 → XP_017448823.1  adhesion G protein-coupled receptor B2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GF79
    Conserved Domains (5) summary
    smart00303
    Location:863 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:521 → 585
    HormR; Domain present in hormone receptors
    smart00209
    Location:357 → 407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:922 → 1191
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:605 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  4. XM_017593335.1 → XP_017448824.1  adhesion G protein-coupled receptor B2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K6N2, A0A8I6GF79
    Related
    ENSRNOP00000073878.2, ENSRNOT00000088568.3
    Conserved Domains (5) summary
    smart00303
    Location:863 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:521 → 585
    HormR; Domain present in hormone receptors
    smart00209
    Location:357 → 407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:922 → 1158
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:605 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  5. XM_017593336.1 → XP_017448825.1  adhesion G protein-coupled receptor B2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GF79
    Conserved Domains (5) summary
    smart00303
    Location:863 → 916
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:521 → 585
    HormR; Domain present in hormone receptors
    smart00209
    Location:357 → 407
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:922 → 1158
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:605 → 762
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  6. XM_017593338.1 → XP_017448827.1  adhesion G protein-coupled receptor B2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A0N9, A0A8I6GF79
    Conserved Domains (5) summary
    smart00303
    Location:808 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:466 → 530
    HormR; Domain present in hormone receptors
    smart00209
    Location:304 → 352
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:867 → 1136
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:550 → 707
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  7. XM_017593340.1 → XP_017448829.1  adhesion G protein-coupled receptor B2 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GF79
    Related
    ENSRNOP00000108277.1, ENSRNOT00000138640.1
    Conserved Domains (5) summary
    smart00303
    Location:808 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:466 → 530
    HormR; Domain present in hormone receptors
    smart00209
    Location:304 → 352
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:867 → 1103
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:550 → 707
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  8. XM_017593337.1 → XP_017448826.1  adhesion G protein-coupled receptor B2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZJF8, A0A8I6GF79
    Related
    ENSRNOP00000077311.1, ENSRNOT00000100313.2
    Conserved Domains (5) summary
    smart00303
    Location:808 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:466 → 530
    HormR; Domain present in hormone receptors
    smart00209
    Location:302 → 352
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:867 → 1136
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:550 → 707
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  9. XM_017593339.1 → XP_017448828.1  adhesion G protein-coupled receptor B2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GF79
    Conserved Domains (5) summary
    smart00303
    Location:808 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:466 → 530
    HormR; Domain present in hormone receptors
    smart00209
    Location:302 → 352
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:867 → 1103
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:550 → 707
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  10. XM_039109800.1 → XP_038965728.1  adhesion G protein-coupled receptor B2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6GF79
    Conserved Domains (7) summary
    smart00303
    Location:808 → 861
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:466 → 530
    HormR; Domain present in hormone receptors
    smart00209
    Location:302 → 352
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:549 → 706
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:26 → 220
    AGRB_N; Adhesion GPCR B N-terminal region
    cd14964
    Location:869 → 894
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:867 → 1124
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  11. XM_039109801.1 → XP_038965729.1  adhesion G protein-coupled receptor B2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6GF79
    Related
    ENSRNOP00000084957.2, ENSRNOT00000114531.2
    Conserved Domains (6) summary
    smart00303
    Location:753 → 806
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:411 → 475
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:812 → 1102
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:494 → 651
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:26 → 220
    AGRB_N; Adhesion GPCR B N-terminal region
Nucleotide Protein Strain
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