U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dnc dunce [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31309, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
dncprovided by FlyBase
Official Full Name
dunceprovided by FlyBase
Primary source
FLYBASE:FBgn0000479
Locus tag
Dmel_CG32498
See related
AllianceGenome:FB:FBgn0000479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10791; CG10792; CG10797; CG14267; CG14268; CG32498; Dmel\CG32498; Dnc; DNC; Dunce; Dunce PDE; EG:140G11.4; EG:96G10.7; EG:BACN05I09.3; EG:BACN5I9.2; fs(1)M42; PDE; PDE4; PDEII
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including axon extension; learning or memory; and thermosensory behavior. Located in cytosol and nucleus. Is expressed in several structures, including Kenyon cell; gland; mushroom body; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in acrodysostosis and alcohol dependence. Orthologous to several human genes including PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dnc in Genome Data Viewer
Location:
3C9-3D1; 1-2 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3176440..3343767)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3070473..3237800)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Follicle cell protein 3C Neighboring gene uncharacterized protein Neighboring gene new glue 2 Neighboring gene new glue 3 Neighboring gene new glue 1 Neighboring gene Pre-intermoult gene 1 Neighboring gene new glue 4 Neighboring gene Salivary gland secretion 4 Neighboring gene long non-coding RNA:CR44886 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46243 Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene Myc

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Defective cyclic adenosine 3':5'-monophosphate phosphodiesterase in the Drosophila memory mutant dunce. Kauvar LM. J Neurosci, 1982 Oct. PMID 6288893, Free PMC Article
  2. Copia RNA levels are elevated in dunce mutants and modulated by cAMP. Yun YD, et al. Nucleic Acids Res, 1989 Oct 25. PMID 2478960, Free PMC Article
  3. Ca2(+)-dependent proteolytic modification of the cAMP-dependent protein kinase in Drosophila wild-type and dunce memory mutants. Müller U, et al. J Neurogenet, 1989 Nov. PMID 2560483
  4. Altered autophosphorylation of adenosine 3',5'-phosphate-dependent protein kinase in the dunce memory mutant of Drosophila melanogaster. Dévay P, et al. Neuroscience, 1986 May. PMID 3016598
  5. Molecular analysis of cDNA clones and the corresponding genomic coding sequences of the Drosophila dunce+ gene, the structural gene for cAMP phosphodiesterase. Chen CN, et al. Proc Natl Acad Sci U S A, 1986 Dec. PMID 3025834, Free PMC Article

See all (465) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dunce activity in serotonergic neurons acts as a long-term memory checkpoint.
    Title: Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons.
  2. Hangover acts as a nuclear RNA binding protein and we identified the phosphodiesterase 4d ortholog dunce as a target RNA.
    Title: Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce.
  3. dunce knockdown in the mushroom body neurons impairs memory without significantly affecting acquisition.
    Title: Identification of genes that promote or inhibit olfactory memory formation in Drosophila.
  4. Dunce phosphodiesterase plays a major role in the spatial regulation of cAMP dynamics.
    Title: PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.
  5. flies responding to visual novelty revealed attention-like processes with stereotypical temporal properties; these processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga
    Title: Attention-like processes in Drosophila require short-term memory genes.
  6. These results indicate that calcium influx through acetylcholine receptors is increased in dunce and that calcium extrusion to the outside and/or calcium buffering are enhanced in dunce.
    Title: Increased calcium influx through acetylcholine receptors in dunce neurons.
  7. Choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways
    Title: Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

mobile_element

  • Loc: 3178521-3186128 mobile_element_type = transposon:opus{}33

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in courtship behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nonassociative learning TAS
Traceable Author Statement
more info
 PubMed 
involved_in olfactory learning TAS
Traceable Author Statement
more info
 PubMed 
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in thermosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dunce
Names
CG32498-PA
CG32498-PB
CG32498-PC
CG32498-PD
CG32498-PE
CG32498-PF
CG32498-PG
CG32498-PI
CG32498-PJ
CG32498-PL
CG32498-PN
CG32498-PP
CG32498-PQ
CG32498-PR
CG32498-PS
CG32498-PT
CG32498-PU
dnc-PA
dnc-PB
dnc-PC
dnc-PD
dnc-PE
dnc-PF
dnc-PG
dnc-PI
dnc-PJ
dnc-PL
dnc-PN
dnc-PP
dnc-PQ
dnc-PR
dnc-PS
dnc-PT
dnc-PU
dunce phosphodiesterase
phosphodiesterase
NP_001259201.1
NP_001259202.1
NP_001259203.1
NP_525061.2
NP_726846.1
NP_726847.2
NP_726849.1
NP_726850.1
NP_726851.3
NP_726852.2
NP_726853.2
NP_726854.2
NP_726855.1
NP_726856.1
NP_726857.1
NP_726858.2
NP_726859.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3176440..3343767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166959.2 → NP_726846.1  dunce, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726846.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4T4
    UniProtKB/TrEMBL
    H8F4P8, Q8MS17
    Related
    FBpp0305507
    Conserved Domains (1) summary
    pfam00233
    Location:870 → 1111
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. NM_001272274.1 → NP_001259203.1  dunce, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1
    Conserved Domains (1) summary
    pfam00233
    Location:376 → 617
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_166963.2 → NP_726851.3  dunce, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726851.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1
    Conserved Domains (1) summary
    pfam00233
    Location:376 → 617
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. NM_166960.3 → NP_726847.2  dunce, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726847.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4T4
    UniProtKB/TrEMBL
    H8F4P8, Q8MS17
    Related
    FBpp0070485
    Conserved Domains (1) summary
    pfam00233
    Location:870 → 1111
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. NM_001272272.1 → NP_001259201.1  dunce, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1, M9PDN2
    Conserved Domains (1) summary
    pfam00233
    Location:303 → 544
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. NM_166968.3 → NP_726856.1  dunce, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726856.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRU5, Q9W4S9
    UniProtKB/TrEMBL
    D0IQA0
    Related
    FBpp0070495
    Conserved Domains (1) summary
    pfam00233
    Location:644 → 885
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  7. NM_166961.2 → NP_726849.1  dunce, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PGD1, M9PGX1, O76918, P12252, Q8IRU3, Q8IRU6, Q8IRU8, Q8IRV0, Q8MRN3, Q8T8M0, Q9NF62, Q9W4S8, Q9W4T0, Q9W4T1
    UniProtKB/TrEMBL
    E2QD73
    Related
    FBpp0070487
    Conserved Domains (1) summary
    pfam00233
    Location:731 → 972
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  8. NM_166964.2 → NP_726852.2  dunce, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726852.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12252
    Related
    FBpp0070491
    Conserved Domains (1) summary
    pfam00233
    Location:729 → 970
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  9. NM_166965.2 → NP_726853.2  dunce, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726853.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PGD1, M9PGX1, O76918, P12252, Q8IRU3, Q8IRU6, Q8IRU8, Q8IRV0, Q8MRN3, Q8T8M0, Q9NF62, Q9W4S8, Q9W4T0, Q9W4T1
    UniProtKB/TrEMBL
    E2QD73
    Related
    FBpp0070489
    Conserved Domains (1) summary
    pfam00233
    Location:731 → 972
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  10. NM_166962.2 → NP_726850.1  dunce, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12252
    Related
    FBpp0070488
    Conserved Domains (1) summary
    pfam00233
    Location:718 → 959
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  11. NM_001272273.1 → NP_001259202.1  dunce, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1
    Conserved Domains (1) summary
    pfam00233
    Location:364 → 605
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  12. NM_166966.3 → NP_726854.2  dunce, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726854.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1
    Conserved Domains (1) summary
    pfam00233
    Location:364 → 605
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  13. NM_166967.2 → NP_726855.1  dunce, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1
    Related
    FBpp0070493
    Conserved Domains (1) summary
    pfam00233
    Location:362 → 603
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  14. NM_166969.2 → NP_726857.1  dunce, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPC1, M9PDN2
    Related
    FBpp0070494
    Conserved Domains (1) summary
    pfam00233
    Location:303 → 544
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  15. NM_166970.2 → NP_726858.2  dunce, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726858.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQA0
    Related
    FBpp0070496
    Conserved Domains (1) summary
    pfam00233
    Location:475 → 716
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  16. NM_080322.3 → NP_525061.2  dunce, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525061.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRU4
    UniProtKB/TrEMBL
    C9QPC1
    Related
    FBpp0070497
    Conserved Domains (1) summary
    pfam00233
    Location:323 → 564
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  17. NM_166971.2 → NP_726859.2  dunce, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726859.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12252
    Related
    FBpp0070498
    Conserved Domains (1) summary
    pfam00233
    Location:182 → 423
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QD73 E2QD73
H8F4P8 H8F4P8
M9PDN2 M9PDN2
P12252.4 P12252
Q8IRU4.1 Q8IRU4
Q8MS17 Q8MS17
Q9W4S9.2 Q9W4S9
Q9W4T4.2 Q9W4T4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous