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Mms22l MMS22-like, DNA repair protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 313108, updated on 27-Nov-2024

Summary

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Official Symbol
Mms22lprovided by RGD
Official Full Name
MMS22-like, DNA repair proteinprovided by RGD
Primary source
RGD:1304693
See related
EnsemblRapid:ENSRNOG00000006996 AllianceGenome:RGD:1304693
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304693
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 87.6), Spleen (RPKM 87.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mms22l in Genome Data Viewer
Location:
5q21
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (42994382..43110371)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (38197707..38313745)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (38844502..38960989)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 10 Neighboring gene uncharacterized LOC134478950 Neighboring gene aldo-keto reductase family 1 member B1-like Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene kelch-like family member 32 Neighboring gene uncharacterized LOC134478952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. O'Donnell L, et al. Mol Cell, 2010 Nov 24. PMID 21055983, Free PMC Article
  2. Identification of the MMS22L-TONSL complex that promotes homologous recombination. Duro E, et al. Mol Cell, 2010 Nov 24. PMID 21055984
  3. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. O'Connell BC, et al. Mol Cell, 2010 Nov 24. PMID 21055985, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FACT complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MMS22-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135780.1 → NP_001129252.1  protein MMS22-like

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZS39
    Related
    ENSRNOP00000009545.5, ENSRNOT00000009545.8
    Conserved Domains (2) summary
    pfam14910
    Location:26 → 729
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:848 → 1224
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    42994382..43110371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109818.2 → XP_038965746.1  protein MMS22-like isoform X1

    Conserved Domains (2) summary
    pfam14910
    Location:26 → 729
    MMS22L_N; S-phase genomic integrity recombination mediator, N-terminal
    pfam14911
    Location:848 → 1072
    MMS22L_C; S-phase genomic integrity recombination mediator, C-terminal

  2. XM_063287584.1 → XP_063143654.1  protein MMS22-like isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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