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Dcaf10 DDB1 and CUL4 associated factor 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313242, updated on 4-Jan-2025

Summary

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Official Symbol
Dcaf10provided by RGD
Official Full Name
DDB1 and CUL4 associated factor 10provided by RGD
Primary source
RGD:1304730
See related
EnsemblRapid:ENSRNOG00000011655 AllianceGenome:RGD:1304730
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wdr32; RGD1304730
Summary
Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF10 (DDB1 and CUL4 associated factor 10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 94.2), Lung (RPKM 68.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dcaf10 in Genome Data Viewer
Location:
5q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64402307..64442839)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59607795..59647209)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60900390..60937547)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486935 Neighboring gene exosome component 3 Neighboring gene phosphoglycerate mutase 1, pseudogene 8 Neighboring gene DDB1 and CUL4 associated factor 10 like Neighboring gene solute carrier family 25, member 51 Neighboring gene SH2 domain containing adaptor protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 10
Names
WD repeat domain 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107935.1 → NP_001101405.1  DDB1- and CUL4-associated factor 10

    See identical proteins and their annotated locations for NP_001101405.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473962
    UniProtKB/TrEMBL
    A6IJ94, D4A8G6
    Related
    ENSRNOP00000016384.5, ENSRNOT00000016384.7
    Conserved Domains (3) summary
    smart00320
    Location:521 → 559
    WD40; WD40 repeats
    sd00039
    Location:176 → 211
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:168 → 323
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    64402307..64442839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238066.5 → XP_006238128.1  DDB1- and CUL4-associated factor 10 isoform X1

    Conserved Domains (3) summary
    smart00320
    Location:455 → 493
    WD40; WD40 repeats
    COG2319
    Location:173 → 493
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:168 → 227
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_010066397.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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