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Parg Poly(ADP-ribose) glycohydrolase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31329, updated on 9-Dec-2024

Summary

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Official Symbol
Pargprovided by FlyBase
Official Full Name
Poly(ADP-ribose) glycohydrolaseprovided by FlyBase
Primary source
FLYBASE:FBgn0023216
Locus tag
Dmel_CG2864
See related
AllianceGenome:FB:FBgn0023216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2864; Dmel\CG2864; dParg; EG:114E2.1; HD10914; parg; PARG
Summary
Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in several processes, including Cajal body organization; female germ-line stem cell population maintenance; and regulation of gene expression. Located in nucleoplasm. Is active in site of DNA damage. Used to study stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Parg in Genome Data Viewer
Location:
3E2-3E2; 1-4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3668837..3671502, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3562870..3565535, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dpr-interacting protein alpha Neighboring gene pickpocket 8 Neighboring gene uncharacterized protein Neighboring gene Allatostatin A receptor 1 Neighboring gene Insulin-like peptide 7 Neighboring gene long non-coding RNA:CR45102 Neighboring gene Mnt

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Hanai S, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14676324, Free PMC Article
  2. PARG Protein Regulation Roles in Drosophila Longevity Control. Bordet G, et al. Int J Mol Sci, 2024 Jun 4. PMID 38892377, Free PMC Article
  3. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Ghosh SG, et al. Am J Hum Genet, 2018 Sep 6. PMID 30100084, Free PMC Article
  4. Poly(ADP-ribosyl)ating enzymes coordinate changes in the expression of metabolic genes with developmental progression. Bordet G, et al. Sci Rep, 2023 Nov 20. PMID 37985852, Free PMC Article
  5. Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control. Bordet G, et al. Life Sci Alliance, 2022 Mar. PMID 34949666, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PARG Protein Regulation Roles in Drosophila Longevity Control.
    Title: PARG Protein Regulation Roles in Drosophila Longevity Control.
  2. loss of function mutant exhibits lethality in the larval stages at the normal development temperature of 25 degrees C
    Title: Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ADP-ribosylserine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(ADP-ribose) glycohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(ADP-ribose) glycohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Cajal body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Poly(ADP-ribose) glycohydrolase
Names
CG2864-PB
CG2864-PC
Parg-PB
Parg-PC
Poly(ADP-ribose)glycohydrolase
Poly(ADPribose) glyco-hydrolase
NP_001245511.1
NP_477321.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3668837..3671502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057973.4 → NP_477321.2  Poly(ADP-ribose) glycohydrolase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477321.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEU9, O46043, Q960N8
    Conserved Domains (1) summary
    pfam05028
    Location:155 → 492
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  2. NM_001258582.2 → NP_001245511.1  Poly(ADP-ribose) glycohydrolase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245511.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEU9, O46043, Q960N8
    Conserved Domains (1) summary
    pfam05028
    Location:155 → 492
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46043.3 O46043

Gene LinkOut

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