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Dennd4c DENN domain containing 4C [ Rattus norvegicus (Norway rat) ]

Gene ID: 313340, updated on 27-Nov-2024

Summary

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Symbol
Dennd4cprovided by RGD
Full Name
DENN domain containing 4Cprovided by RGD
Primary source
RGD:1308489
See related
EnsemblRapid:ENSRNOG00000008036 AllianceGenome:RGD:1308489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308489
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to insulin stimulus and protein localization to plasma membrane. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and insulin-responsive compartment. Predicted to be part of retromer complex. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 233.6), Adrenal (RPKM 232.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dennd4c in Genome Data Viewer
Location:
5q32
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106316942..106421484)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101272298..101369529)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (105100081..105195634)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene perilipin 2 Neighboring gene uncharacterized LOC102547623 Neighboring gene uncharacterized LOC134486947 Neighboring gene ribosomal protein S6 Neighboring gene alkaline ceramidase 2 Neighboring gene uncharacterized LOC134486948 Neighboring gene small ribosomal subunit protein uS10-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320. Zhang J, et al. Cell Cycle, 2020 Nov. PMID 33090893, Free PMC Article
  2. Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. Borner GH, et al. J Cell Biol, 2012 Apr 2. PMID 22472443, Free PMC Article
  3. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Klip A, et al. Am J Physiol Cell Physiol, 2014 May 15. PMID 24598362
  4. Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. Sano H, et al. J Biol Chem, 2011 May 13. PMID 21454697, Free PMC Article
  5. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320.
    Title: Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 4C
Names
DENN/MADD domain containing 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427785.1 → NP_001414714.1  DENN domain-containing protein 4C

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K089
    Related
    ENSRNOP00000102197.1, ENSRNOT00000159225.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    106316942..106421484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111089.2 → XP_038967017.1  DENN domain-containing protein 4C isoform X1

    Related
    ENSRNOP00000071348.3, ENSRNOT00000082596.3
    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:193 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  2. XM_039111092.2 → XP_038967020.1  DENN domain-containing protein 4C isoform X3

    Conserved Domains (4) summary
    smart00801
    Location:559 → 632
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:193 → 276
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:820 → 849
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:309 → 492
    DENN; DENN (AEX-3) domain

  3. XM_039111090.2 → XP_038967018.1  DENN domain-containing protein 4C isoform X2

    Conserved Domains (4) summary
    smart00801
    Location:323 → 396
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:584 → 613
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:73 → 256
    DENN; DENN (AEX-3) domain
    cl04085
    Location:1 → 40
    uDENN; uDENN domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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