U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dock7 dedicator of cytokinesis 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313388, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dock7provided by RGD
Official Full Name
dedicator of cytokinesis 7provided by RGD
Primary source
RGD:1309790
See related
EnsemblRapid:ENSRNOG00000008298 AllianceGenome:RGD:1309790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of cold-induced thermogenesis; and nervous system development. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Predicted to be part of COP9 signalosome. Predicted to be active in neuromuscular junction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 129.9), Heart (RPKM 123.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dock7 in Genome Data Viewer
Location:
5q33
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (118714863..118898362, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (113599371..113782871, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (117595194..117780844, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 15, pseudogene 2 Neighboring gene ubiquitin specific peptidase 1 Neighboring gene angiopoietin-like 3 Neighboring gene noelin-like Neighboring gene ribosomal protein L15, pseudogene 14 Neighboring gene autophagy related 4C, cysteine peptidase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells. Majewski Ł, et al. Biochem Cell Biol, 2012 Aug. PMID 22475431
  2. Altered thermogenesis and impaired bone remodeling in Misty mice. Motyl KJ, et al. J Bone Miner Res, 2013 Sep. PMID 23553822, Free PMC Article
  3. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. Sobczak M, et al. Biochim Biophys Acta, 2016 Jul. PMID 27018747
  4. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Watabe-Uchida M, et al. Neuron, 2006 Sep 21. PMID 16982419
  5. DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Yang YT, et al. Nat Neurosci, 2012 Sep. PMID 22842144, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC189434

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of neuroblast polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in interkinetic nuclear migration ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic specialization assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dedicator of cytokinesis protein 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415885.1 → NP_001402814.1  dedicator of cytokinesis protein 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K3H2
    Related
    ENSRNOP00000089895.2, ENSRNOT00000100273.2

  2. NM_001415886.1 → NP_001402815.1  dedicator of cytokinesis protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    118714863..118898362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287647.1 → XP_063143717.1  dedicator of cytokinesis protein 7 isoform X5

  2. XM_063287651.1 → XP_063143721.1  dedicator of cytokinesis protein 7 isoform X9

  3. XM_063287646.1 → XP_063143716.1  dedicator of cytokinesis protein 7 isoform X4

  4. XM_063287644.1 → XP_063143714.1  dedicator of cytokinesis protein 7 isoform X2

    Related
    ENSRNOP00000063286.3, ENSRNOT00000065112.4

  5. XM_063287645.1 → XP_063143715.1  dedicator of cytokinesis protein 7 isoform X3

    Related
    ENSRNOP00000098970.1, ENSRNOT00000156393.1

  6. XM_063287643.1 → XP_063143713.1  dedicator of cytokinesis protein 7 isoform X1

    Related
    ENSRNOP00000072637.3, ENSRNOT00000081971.3

  7. XM_063287649.1 → XP_063143719.1  dedicator of cytokinesis protein 7 isoform X7

  8. XM_063287648.1 → XP_063143718.1  dedicator of cytokinesis protein 7 isoform X6

  9. XM_063287650.1 → XP_063143720.1  dedicator of cytokinesis protein 7 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191574.2: Suppressed sequence

    Description
    NM_001191574.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools