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Klhl13 kelch-like family member 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313445, updated on 9-Dec-2024

Summary

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Official Symbol
Klhl13provided by RGD
Official Full Name
kelch-like family member 13provided by RGD
Primary source
RGD:1559646
See related
EnsemblRapid:ENSRNOG00000014029 AllianceGenome:RGD:1559646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL13 (kelch like family member 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 107.3), Muscle (RPKM 78.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl13 in Genome Data Viewer
Location:
Xq34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (118747298..118912279, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (113942309..114107299, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (121578965..121735014, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Sec61 translocon subunit gamma, pseudogene 4 Neighboring gene ribosomal protein S26, pseudogene 7 Neighboring gene uncharacterized LOC108349247 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120099301

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Sumara I, et al. Dev Cell, 2007 Jun. PMID 17543862
  2. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa M, et al. Nat Cell Biol, 2003 Nov. PMID 14528312
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100854.1 → NP_001094324.1  kelch-like protein 13 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5ZU85, A0A8I6A140, A6JMD3

  2. NM_001401131.1 → NP_001388060.1  kelch-like protein 13 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6AHM2, F1LM44
    Related
    ENSRNOP00000018788.6, ENSRNOT00000018788.10
    Conserved Domains (3) summary
    PHA03098
    Location:97 → 640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384 → 432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74 → 201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  3. NM_001401132.1 → NP_001388061.1  kelch-like protein 13 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5ZU85, A0A8I6A901
    Related
    ENSRNOP00000090232.1, ENSRNOT00000101919.2

  4. NM_001401133.1 → NP_001388062.1  kelch-like protein 13 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I5ZU85, A0A8I6A140, A6JMD3
    Related
    ENSRNOP00000084359.1, ENSRNOT00000111718.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    118747298..118912279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100612.2 → XP_038956540.1  kelch-like protein 13 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHM2, F1LM44
    Conserved Domains (3) summary
    PHA03098
    Location:97 → 640
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:384 → 432
    Kelch; KELCH repeat [structural motif]
    cd18239
    Location:74 → 201
    BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

  2. XM_003752130.6 → XP_003752178.1  kelch-like protein 13 isoform X2

    See identical proteins and their annotated locations for XP_003752178.1

    UniProtKB/TrEMBL
    A0A8I5ZU85, A0A8I6A5N5
    Related
    ENSRNOP00000088723.1, ENSRNOT00000094972.2
    Conserved Domains (6) summary
    smart00612
    Location:445 → 490
    Kelch; Kelch domain
    PHA03098
    Location:94 → 637
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:381 → 429
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:84 → 190
    BTB; BTB/POZ domain
    pfam01344
    Location:380 → 430
    Kelch_1; Kelch motif
    pfam07707
    Location:198 → 299
    BACK; BTB And C-terminal Kelch

  3. XM_063279989.1 → XP_063136059.1  kelch-like protein 13 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZU85
    Related
    ENSRNOP00000082058.1, ENSRNOT00000106563.2

  4. XM_006257444.5 → XP_006257506.1  kelch-like protein 13 isoform X3

    See identical proteins and their annotated locations for XP_006257506.1

    UniProtKB/TrEMBL
    A0A8I5ZU85, A0A8I6AB93
    Related
    ENSRNOP00000088688.1, ENSRNOT00000094168.2
    Conserved Domains (6) summary
    smart00612
    Location:442 → 487
    Kelch; Kelch domain
    PHA03098
    Location:91 → 634
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:378 → 426
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:81 → 187
    BTB; BTB/POZ domain
    pfam01344
    Location:377 → 427
    Kelch_1; Kelch motif
    pfam07707
    Location:195 → 296
    BACK; BTB And C-terminal Kelch
Nucleotide Protein Strain
Heading Accession and Version

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