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Vap33 - VAMP-associated protein 33kDa

Predicted to enable protein-membrane adaptor activity. Involved in several processes, including cytoplasmic microtubule organization; defense response to Gram-negative bacterium; and synapse organization. Located in endoplasmic reticulum; extracellular space; and plasma membrane. Is active in several cellular components, including cholinergic synapse; presynaptic cytoskeleton; and presynaptic membrane. Is expressed in adult head; adult heart; and organism. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; motor neuron disease; and neurodegenerative disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to several human genes including VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Vap33

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Species Gene Architecture aa