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Cmtr1 Cap methyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31355, updated on 4-Jan-2025

Summary

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Official Symbol
Cmtr1provided by FlyBase
Official Full Name
Cap methyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0029693
Locus tag
Dmel_CG6379
See related
AllianceGenome:FB:FBgn0029693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6379; CMTr1; dCMTR1; Dmel\CG6379
Summary
Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping and RISC complex assembly. Located in cytoplasm and nucleus. Is expressed in adult head. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cmtr1 in Genome Data Viewer
Location:
4A5-4A5; 1-6 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4097592..4101031, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3991625..3995064, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46349 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum group A-like Neighboring gene brainiac

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CMTr mediated 2'-O-ribose methylation status of cap-adjacent nucleotides across animals. Dix TC, et al. RNA, 2022 Oct. PMID 35970556, Free PMC Article
  2. Roles for Drosophila cap1 2'-O-ribose methyltransferase in the small RNA silencing pathway associated with Argonaute 2. Lee S, et al. Insect Biochem Mol Biol, 2020 Aug. PMID 32504809
  3. CMTr cap-adjacent 2'-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses. Haussmann IU, et al. Nat Commun, 2022 Mar 8. PMID 35260552, Free PMC Article
  4. A genetic screen to uncover mechanisms underlying lipid transfer protein function at membrane contact sites. Mishra S, et al. Life Sci Alliance, 2024 Jun. PMID 38499328, Free PMC Article
  5. Biochemical identification of new proteins involved in splicing repression at the Drosophila P-element exonic splicing silencer. Horan L, et al. Genes Dev, 2015 Nov 1. PMID 26545814, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine mRNA capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 7-methylguanosine mRNA capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RISC complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of intracellular mRNA localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Cap methyltransferase 1
Names
CG6379-PA
CG6379-PB
Cmtr1-PA
Cmtr1-PB
cap1 2'-O-MTase
cap1 2'-O-ribose methyltransferase
NP_001284851.1
NP_572148.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4097592..4101031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297922.1 → NP_001284851.1  Cap methyltransferase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9YI61, Q8SYG1, Q9W4N2
    UniProtKB/TrEMBL
    T2GGJ9
    Conserved Domains (2) summary
    pfam01585
    Location:25 → 69
    G-patch; G-patch domain
    pfam01728
    Location:172 → 383
    FtsJ; FtsJ-like methyltransferase

  2. NM_131920.4 → NP_572148.2  Cap methyltransferase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572148.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9YI61, Q8SYG1, Q9W4N2
    UniProtKB/TrEMBL
    T2GGJ9
    Related
    FBpp0070639
    Conserved Domains (2) summary
    pfam01585
    Location:25 → 69
    G-patch; G-patch domain
    pfam01728
    Location:172 → 383
    FtsJ; FtsJ-like methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4N2.1 Q9W4N2
T2GGJ9 T2GGJ9

Gene LinkOut

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