Rspo1 R-spondin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rspo1provided by RGD
Official Full Name: R-spondin 1provided by RGD
Primary source: RGD:1565558
See related: EnsemblRapid:ENSRNOG00000009656 AllianceGenome:RGD:1565558
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565558
Summary: Predicted to enable G protein-coupled receptor binding activity and heparin binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of protein phosphorylation; and regulation of receptor internalization. Predicted to act upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulation of male germ cell proliferation. Predicted to be located in nucleus. Predicted to be active in extracellular space. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 33.9), Lung (RPKM 32.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (142536162..142557611)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (137251629..137273273)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (142986526..143007847)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circuits in the brain to regulate energy homeostasis.
Title: LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:498602 (e-PCR)
- UniSTS:498602

Rspo1 (e-PCR), detects polymorphism
- UniSTS:498602

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of male germ cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: R-spondin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107980.1 → NP_001101450.1 R-spondin-1 precursor

See identical proteins and their annotated locations for NP_001101450.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6IS66, D3ZBD1

Conserved Domains (3) summary

cd00064
Location:100 → 142

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam15913
Location:42 → 144

Furin-like_2; Furin-like repeat, cysteine-rich

cl15278
Location:151 → 216

TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

142536162..142557611

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287752.1 → XP_063143822.1 R-spondin-1 isoform X1

UniProtKB/TrEMBL

A6IS66, D3ZBD1

Related

ENSRNOP00000098861.1, ENSRNOT00000158619.1
XM_008764019.4 → XP_008762241.1 R-spondin-1 isoform X1

See identical proteins and their annotated locations for XP_008762241.1

UniProtKB/TrEMBL

A6IS66, D3ZBD1

Related

ENSRNOP00000012811.4, ENSRNOT00000012811.7

Conserved Domains (3) summary

cd00064
Location:100 → 142

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam15913
Location:42 → 144

Furin-like_2; Furin-like repeat, cysteine-rich

cl15278
Location:151 → 216

TSP_1; Thrombospondin type 1 domain
XM_039110013.2 → XP_038965941.1 R-spondin-1 isoform X2

Conserved Domains (2) summary

pfam15913
Location:23 → 78

Furin-like_2; Furin-like repeat, cysteine-rich

pfam19028
Location:84 → 139

TSP1_spondin; Spondin-like TSP1 domain