Fas2 Fasciclin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fas2provided by FlyBase
Official Full Name: Fasciclin 2provided by FlyBase
Primary source: FLYBASE:FBgn0000635
Locus tag: Dmel_CG3665
See related: AllianceGenome:FB:FBgn0000635
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1D4; Ab 1D4; anon-EST:Liang-1.60; CG3665; clone 1.60; CT12301; Dmel\CG3665; EG:EG0007.3; Fas; FAS 11; Fas 2; fas II; Fas II; FAS II; fas-II; Fas-II; fas2; FAS2; Fasc II; fasciclin II; FascII; fasII; Fasii; FasII; FASII; l(1)G0032; l(1)G0048; l(1)G0081; l(1)G0293; l(1)G0336; mAb 1D4; mAb1D4; mAB1D4; MAB1D4
Summary: Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including neuron development; regulation of tube size, open tracheal system; and synapse organization. Located in several cellular components, including distal axon; muscle cell postsynaptic specialization; and synaptic membrane. Is expressed in several structures, including neurohemal organ; neuron projection bundle; neurons; presumptive embryonic/larval system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1) and NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 4B1-4B3; 1-7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4132887..4206093, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4026920..4100126, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fas2 has function(s) other than homophilic adhesion.
Title: The Drosophila NCAM homolog Fas2 signals independently of adhesion.
Study identifies Fas2 as miR-210's target in circadian regulation. Fas2 abundance is increased in fly brain lacking of miR-210 suggesting that Fas2 expression is inhibited by miR-210 determining the phase of evening anticipatory behavior.
Title: miR-210 controls the evening phase of circadian locomotor rhythms through repression of Fasciclin 2.
Fas2-mediated intermicrovillar homophilic adhesion complexes help stabilize the brush border.
Title: The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules.
Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII.
Title: C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
Fas 2 is linked to core clock by Mef2 and influences circadian cycle within pacemaker neurons; Mef2 is required for this daily fasciculation-defasciculation cycle
Title: The transcription factor Mef2 links the Drosophila core clock to Fas2, neuronal morphology, and circadian behavior.
the expression of Adf-1 targets Staufen and Fasciclin II (FasII), identified through larval brain ChIP-Seq for Adf-1, is negatively regulated by Adf-1, and manipulations of these genes predictably modify dendrite growth.
Title: The Drosophila transcription factor Adf-1 (nalyot) regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity.
Together with our results suggesting that DmRet and DmGfrl do not function in cis in Drosophila, which lacks GDNF ligands, these data imply that DmGfrl may be an evolutionarily ancient binding partner for NCAM/FasII.
Title: Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII.
The inability of Tao mutant cells to shorten their membranes is caused by the accumulation of the cell adhesion molecule Fasciclin 2.
Title: Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis.
this FasII isoform has unique functions in synaptic development independent of transsynaptic adhesion. beag and dsmu1 mutants demonstrate an essential role for these previously uncharacterized splicing factors in the regulation of synapse development
Title: Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag.
Loss of fas2 interacts with genetic conditions that perturb EGFR signalling. Fas2 is expressed in patterns during imaginal disc development, and in eye we have shown that this depends on EGFR activity, implying participation in a negative-feedback loop.
Title: Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0365 (e-PCR)
- UniSTS:30638

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in Bolwig's organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonal fasciculation	TAS Traceable Author Statement more info	PubMed
involved_in behavioral response to ethanol	TAS Traceable Author Statement more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis involved in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in olfactory learning	TAS Traceable Author Statement more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotor rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse structure or activity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tube diameter, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	TAS Traceable Author Statement more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in leading edge membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in muscle cell postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynaptic periactive zone	IDA Inferred from Direct Assay more info	PubMed
located_in type I terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fasciclin 2

Names: CG3665-PA; CG3665-PB; CG3665-PC; CG3665-PD; CG3665-PF; CG3665-PG; CG3665-PH; FASCICLIN II; Fas; Fas2-PA; Fas2-PB; Fas2-PC; Fas2-PD; Fas2-PF; Fas2-PG; Fas2-PH; FasciclinII; fasII; fascicilin II; fasciclin; fasciclin-2; fasciclin-II; fasciclin2; fasciculin II; fascilin II; fasiclin II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4132887..4206093 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272308.2 → NP_001259237.1 fasciclin 2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259237.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW6, M9PGF6

Conserved Domains (6) summary

cd00096
Location:462 → 533

Ig; Immunoglobulin domain

smart00408
Location:258 → 324

IGc2; Immunoglobulin C-2 Type

smart00410
Location:159 → 241

IG_like; Immunoglobulin like

cd00063
Location:655 → 750

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:245 → 334

I-set; Immunoglobulin I-set domain

pfam00041
Location:549 → 626

fn3; Fibronectin type III domain
NM_001272306.1 → NP_001259235.1 fasciclin 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259235.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW6, M9PJ19

Conserved Domains (6) summary

cd00096
Location:447 → 518

Ig; Immunoglobulin domain

smart00408
Location:243 → 309

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 226

IG_like; Immunoglobulin like

cd00063
Location:640 → 735

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:230 → 319

I-set; Immunoglobulin I-set domain

pfam00041
Location:534 → 611

fn3; Fibronectin type III domain
NM_080327.3 → NP_525066.1 fasciclin 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525066.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34082, P34083, Q6IDE4, Q8IRS5, Q9W4M6

UniProtKB/TrEMBL

C0PTW6

Related

FBpp0070633

Conserved Domains (6) summary

cd00096
Location:447 → 518

Ig; Immunoglobulin domain

smart00408
Location:243 → 309

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 226

IG_like; Immunoglobulin like

cd00063
Location:640 → 735

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:230 → 319

I-set; Immunoglobulin I-set domain

pfam00041
Location:534 → 611

fn3; Fibronectin type III domain
NM_001297925.1 → NP_001284854.1 fasciclin 2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284854.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW6, X2JAF4

Conserved Domains (6) summary

cd00096
Location:447 → 518

Ig; Immunoglobulin domain

smart00408
Location:243 → 309

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 226

IG_like; Immunoglobulin like

cd00063
Location:640 → 735

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:230 → 319

I-set; Immunoglobulin I-set domain

pfam00041
Location:534 → 611

fn3; Fibronectin type III domain
NM_001297926.1 → NP_001284855.1 fasciclin 2, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284855.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW6, X2JCI0

Conserved Domains (6) summary

cd00096
Location:447 → 518

Ig; Immunoglobulin domain

smart00408
Location:243 → 309

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 226

IG_like; Immunoglobulin like

cd00063
Location:640 → 735

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:230 → 319

I-set; Immunoglobulin I-set domain

pfam00041
Location:534 → 611

fn3; Fibronectin type III domain
NM_167004.2 → NP_726911.1 fasciclin 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726911.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW6

Related

FBpp0070634

Conserved Domains (6) summary

cd00096
Location:447 → 518

Ig; Immunoglobulin domain

smart00408
Location:243 → 309

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 226

IG_like; Immunoglobulin like

cd00063
Location:640 → 735

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:230 → 319

I-set; Immunoglobulin I-set domain

pfam00041
Location:534 → 611

fn3; Fibronectin type III domain
NM_167005.2 → NP_726912.1 fasciclin 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726912.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW6

Related

FBpp0070635

Conserved Domains (6) summary

cd00096
Location:447 → 518

Ig; Immunoglobulin domain

smart00408
Location:243 → 309

IGc2; Immunoglobulin C-2 Type

smart00410
Location:144 → 226

IG_like; Immunoglobulin like

cd00063
Location:640 → 735

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:230 → 319

I-set; Immunoglobulin I-set domain

pfam00041
Location:534 → 611

fn3; Fibronectin type III domain