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Cptp ceramide-1-phosphate transfer protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 313771, updated on 2-Nov-2024

Summary

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Official Symbol
Cptpprovided by RGD
Official Full Name
ceramide-1-phosphate transfer proteinprovided by RGD
Primary source
RGD:1359656
See related
EnsemblRapid:ENSRNOG00000022455 AllianceGenome:RGD:1359656
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gltpd1
Summary
Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in several processes, including ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Predicted to be located in Golgi apparatus; bounding membrane of organelle; and plasma membrane. Predicted to be active in cytosol. Orthologous to human CPTP (ceramide-1-phosphate transfer protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 81.3), Testes (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cptp in Genome Data Viewer
Location:
5q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171757181..171761271, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166474947..166479103, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173314219..173318384, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene matrix remodeling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3 Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridine synthase like 1 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation. Mishra SK, et al. Autophagy, 2018. PMID 29164996, Free PMC Article
  2. Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids. Simanshu DK, et al. Nature, 2013 Aug 22. PMID 23863933, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94339

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide 1-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide 1-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables ceramide 1-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ceramide 1-phosphate transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide 1-phosphate transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables ceramide 1-phosphate transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ceramide 1-phosphate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in ceramide 1-phosphate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in glycolipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ceramide-1-phosphate transfer protein
Names
glycolipid transfer protein domain containing 1
glycolipid transfer protein domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007703.1 → NP_001007704.1  ceramide-1-phosphate transfer protein

    See identical proteins and their annotated locations for NP_001007704.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083599
    UniProtKB/Swiss-Prot
    Q5XIS2
    UniProtKB/TrEMBL
    A6IUT7
    Related
    ENSRNOP00000034006.3, ENSRNOT00000039117.5
    Conserved Domains (1) summary
    pfam08718
    Location:30 → 175
    GLTP; Glycolipid transfer protein (GLTP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171757181..171761271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110121.2 → XP_038966049.1  ceramide-1-phosphate transfer protein isoform X2

    Conserved Domains (1) summary
    pfam08718
    Location:2 → 112
    GLTP; Glycolipid transfer protein (GLTP)

  2. XM_006239576.5 → XP_006239638.1  ceramide-1-phosphate transfer protein isoform X1

    See identical proteins and their annotated locations for XP_006239638.1

    UniProtKB/Swiss-Prot
    Q5XIS2
    UniProtKB/TrEMBL
    A6IUT7
    Conserved Domains (1) summary
    pfam08718
    Location:30 → 175
    GLTP; Glycolipid transfer protein (GLTP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIS2.1 GenPept UniProtKB/Swiss-Prot:Q5XIS2

Gene LinkOut

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