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bi - bifid

Enables DNA binding activity. Involved in several processes, including compound eye morphogenesis; negative regulation of transcription by RNA polymerase II; and wing disc development. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; compartment boundary; head epidermis primordium; imaginal disc; and synaptic neuropil domain. Used to study cancer. Human ortholog(s) of this gene implicated in atrial heart septal defect; heart septal defect; ulnar-mammary syndrome; and vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa