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Usf Usf [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31384, updated on 9-Dec-2024

Summary

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Official Symbol
Usfprovided by FlyBase
Official Full Name
Usfprovided by FlyBase
Primary source
FLYBASE:FBgn0029711
Locus tag
Dmel_CG17592
See related
AllianceGenome:FB:FBgn0029711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHb13; CG17592; Dm Usf; Dmel\CG17592; DmUsf; dUSF; dUSF2
Summary
Enables E-box binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic/larval garland cell; garland cell primordium; head mesoderm; and spermatocyte. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1) and USF2 (upstream transcription factor 2, c-fos interacting). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Usf in Genome Data Viewer
Location:
4C7-4C7; 1-8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4544617..4548794, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4438650..4442827, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR32773 Neighboring gene CHOp24 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition. Wünsch D, et al. Biol Chem, 2015 Apr. PMID 25720119
  2. Promoter contribution to the testis-specific expression of Stellate gene family in Drosophila melanogaster. Olenkina OM, et al. Gene, 2012 May 10. PMID 22425977
  3. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article
  4. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Peyrefitte S, et al. Mech Dev, 2001 Jun. PMID 11404084
  5. The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Ledent V, et al. Genome Res, 2001 May. PMID 11337472, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Usf
Names
CG17592-PB
CG17592-PC
Usf-PB
Usf-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4544617..4548794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167010.3 → NP_726931.2  Usf, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726931.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4J8
    Conserved Domains (1) summary
    pfam00010
    Location:255 → 343
    HLH; Helix-loop-helix DNA-binding domain

  2. NM_131939.6 → NP_572167.3  Usf, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572167.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4J8
    Related
    FBpp0070669
    Conserved Domains (1) summary
    pfam00010
    Location:255 → 343
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JQK3 Q7JQK3
Q9W4J8 Q9W4J8

Gene LinkOut

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