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Hnrnpll heterogeneous nuclear ribonucleoprotein L-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 313842, updated on 9-Dec-2024

Summary

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Official Symbol
Hnrnpllprovided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein L-likeprovided by RGD
Primary source
RGD:1305861
See related
EnsemblRapid:ENSRNOG00000006929 AllianceGenome:RGD:1305861
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnrpll; RGD1305861
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of RNA splicing. Predicted to be active in nucleus and synapse. Orthologous to human HNRNPLL (heterogeneous nuclear ribonucleoprotein L like). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 139.7), Kidney (RPKM 108.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnpll in Genome Data Viewer
Location:
6q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20720013..20752803)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14969953..15000574)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2698983..2729715, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479103 Neighboring gene uncharacterized LOC134479102 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479323 Neighboring gene uncharacterized LOC134479324 Neighboring gene atlastin GTPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Oberdoerffer S, et al. Science, 2008 Aug 1. PMID 18669861, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein L-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    20720013..20752803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_233805.11 → XP_233805.5  heterogeneous nuclear ribonucleoprotein L-like isoform X1

    See identical proteins and their annotated locations for XP_233805.5

    UniProtKB/TrEMBL
    D4A3E1
    Related
    ENSRNOP00000112228.1, ENSRNOT00000145980.1
    Conserved Domains (5) summary
    cd12700
    Location:385 → 455
    RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12705
    Location:501 → 585
    RRM4_hnRPLL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12781
    Location:122 → 205
    RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    cd12786
    Location:214 → 309
    RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
    TIGR01649
    Location:123 → 590
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

  2. XM_039113073.2 → XP_038969001.1  heterogeneous nuclear ribonucleoprotein L-like isoform X2

    Related
    ENSRNOP00000009175.6, ENSRNOT00000009175.8
    Conserved Domains (1) summary
    TIGR01649
    Location:123 → 566
    hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RNA

  1. XR_005505709.2 RNA Sequence

Nucleotide Protein Strain
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