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Pkdcc protein kinase domain containing, cytoplasmic [ Rattus norvegicus (Norway rat) ]

Gene ID: 313860, updated on 9-Dec-2024

Summary

Official Symbol
Pkdccprovided by RGD
Official Full Name
protein kinase domain containing, cytoplasmicprovided by RGD
Primary source
RGD:1311939
See related
AllianceGenome:RGD:1311939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sgk493; RGD1311939
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including negative regulation of Golgi to plasma membrane protein transport; positive regulation of bone mineralization; and positive regulation of chondrocyte differentiation. Predicted to act upstream of or within bone mineralization and limb morphogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular region. Orthologous to human PKDCC (protein kinase domain containing, cytoplasmic). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 176.9), Liver (RPKM 161.3) and 9 other tissues See more
Orthologs
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Genomic context

See Pkdcc in Genome Data Viewer
Location:
6q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (17208171..17217488, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11455686..11465002, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6427657..6436974)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479099 Neighboring gene H3.3 histone A, pseudogene 3 Neighboring gene uncharacterized LOC120103472 Neighboring gene uncharacterized LOC120103473

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
extracellular tyrosine-protein kinase PKDCC
Names
protein kinase domain-containing protein, cytoplasmic
protein kinase-like protein SgK493
sugen kinase 493
NP_001101477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108007.1NP_001101477.1  extracellular tyrosine-protein kinase PKDCC

    See identical proteins and their annotated locations for NP_001101477.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6H9N4, B2GV56
    Conserved Domains (1) summary
    cl21453
    Location:1166
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    17208171..17217488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)