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Alms1a Alstrom syndrome 1a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31393, updated on 9-Dec-2024

Summary

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Official Symbol
Alms1aprovided by FlyBase
Official Full Name
Alstrom syndrome 1aprovided by FlyBase
Primary source
FLYBASE:FBgn0025388
Locus tag
Dmel_CG12179
See related
AllianceGenome:FB:FBgn0025388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alms1a; CG12179; Dmel\CG12179; EG:66A1.2
Summary
Enables kinase binding activity and kinesin binding activity. Involved in male germ-line stem cell asymmetric division; positive regulation of centriole replication; and positive regulation of centrosome duplication. Colocalizes with centriole. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Alms1a in Genome Data Viewer
Location:
4C10-4C10; 1-8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4631052..4636004, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4525085..4530037, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pebbled Neighboring gene Alstrom syndrome 1b Neighboring gene partner of numb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis. Chen C, et al. Elife, 2020 Sep 23. PMID 32965218, Free PMC Article
  2. Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline. Mohr C, et al. Sex Dev, 2017. PMID 28273663
  3. Evolution of alternative splicing in newly evolved genes of Drosophila. Zhan Z, et al. Gene, 2011 Jan 1. PMID 20851753
  4. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Crawford ED, et al. Cell Death Differ, 2012 Dec. PMID 22918439, Free PMC Article
  5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of centriole replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centriole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alstrom syndrome 1a
Names
Alms1a-PC
Alms1a-PD
CG12179-PC
CG12179-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4631052..4636004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167011.4 → NP_726937.3  alstrom syndrome 1a, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726937.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5BI31, Q9W4I8, Q9W4I9
    UniProtKB/TrEMBL
    O77273
    Conserved Domains (2) summary
    PTZ00121
    Location:457 → 587
    PTZ00121; MAEBL; Provisional
    pfam15309
    Location:1190 → 1309
    ALMS_motif; ALMS motif

  2. NM_131947.4 → NP_572175.3  alstrom syndrome 1a, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572175.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5BI31, Q9W4I8, Q9W4I9
    UniProtKB/TrEMBL
    O77273
    Conserved Domains (2) summary
    PTZ00121
    Location:457 → 587
    PTZ00121; MAEBL; Provisional
    pfam15309
    Location:1190 → 1309
    ALMS_motif; ALMS motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77273 O77273
Q5BI31.1 Q5BI31

Gene LinkOut

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