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Itsn2 intersectin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313934, updated on 4-Jan-2025

Summary

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Official Symbol
Itsn2provided by RGD
Official Full Name
intersectin 2provided by RGD
Primary source
RGD:1590890
See related
EnsemblRapid:ENSRNOG00000046741 AllianceGenome:RGD:1590890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in clathrin-dependent synaptic vesicle endocytosis and positive regulation of dendrite extension. Predicted to be located in centrosome. Predicted to be active in cytoplasm; intracellular vesicle; and presynaptic membrane. Orthologous to human ITSN2 (intersectin 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 307.8), Thymus (RPKM 234.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Itsn2 in Genome Data Viewer
Location:
6q14
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33336086..33446818)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27616645..27727373)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (30098378..30208694, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479112 Neighboring gene uncharacterized LOC134479114 Neighboring gene ribosomal protein L29, pseudogene 6 Neighboring gene family with sequence similarity 228, member A Neighboring gene uncharacterized LOC134479113 Neighboring gene family with sequence similarity 228, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. Rodriguez-Fraticelli AE, et al. J Cell Biol, 2010 May 17. PMID 20479469, Free PMC Article
  2. FCHo proteins are nucleators of clathrin-mediated endocytosis. Henne WM, et al. Science, 2010 Jun 4. PMID 20448150, Free PMC Article
  3. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. Yoo JC, et al. J Dermatol Sci, 2013 Dec. PMID 23999003
  4. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. Schmid EM, et al. PLoS Biol, 2006 Sep. PMID 16903783, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
intersectin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427104.1 → NP_001414033.1  intersectin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6ASA9, A6HAI3
    Related
    ENSRNOP00000094789.1, ENSRNOT00000100901.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    33336086..33446818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039113103.2 → XP_038969031.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8K6, M0R7A6
    Related
    ENSRNOP00000065329.3, ENSRNOT00000074150.5
    Conserved Domains (11) summary
    PTZ00121
    Location:347 → 797
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1574 → 1708
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:780 → 836
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:921 → 972
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:1004 → 1055
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1076 → 1134
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1149 → 1202
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1233 → 1413
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1431 → 1574
    PH_13; Pleckstrin homology domain
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  2. XM_039113108.2 → XP_038969036.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AMD2, A6HAI3
    Related
    ENSRNOP00000096723.1, ENSRNOT00000119587.2
    Conserved Domains (11) summary
    cd08375
    Location:1514 → 1648
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:720 → 776
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:861 → 912
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:944 → 995
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1016 → 1074
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1089 → 1142
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1173 → 1353
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    COG1196
    Location:350 → 726
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16652
    Location:1371 → 1514
    PH_13; Pleckstrin homology domain
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  3. XM_063261879.1 → XP_063117949.1  intersectin-2 isoform X9

    UniProtKB/TrEMBL
    A6HAI6

  4. XM_039113102.2 → XP_038969030.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8K6, M0R7A6
    Related
    ENSRNOP00000089614.1, ENSRNOT00000099866.2
    Conserved Domains (11) summary
    PTZ00121
    Location:347 → 797
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1574 → 1708
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:780 → 836
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:921 → 972
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:1004 → 1055
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1076 → 1134
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1149 → 1202
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1233 → 1413
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1431 → 1574
    PH_13; Pleckstrin homology domain
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  5. XM_039113105.2 → XP_038969033.1  intersectin-2 isoform X2

    UniProtKB/TrEMBL
    M0R7A6
    Conserved Domains (11) summary
    cd08375
    Location:1547 → 1681
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:753 → 809
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:894 → 945
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:977 → 1028
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1049 → 1107
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1122 → 1175
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1206 → 1386
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    COG1196
    Location:376 → 753
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam16652
    Location:1404 → 1547
    PH_13; Pleckstrin homology domain
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  6. XM_039113106.2 → XP_038969034.1  intersectin-2 isoform X3

    UniProtKB/TrEMBL
    M0R7A6
    Conserved Domains (10) summary
    PTZ00121
    Location:318 → 768
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1545 → 1679
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:751 → 807
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:892 → 943
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:975 → 1026
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1047 → 1105
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1120 → 1173
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1204 → 1384
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1402 → 1545
    PH_13; Pleckstrin homology domain

  7. XM_063261877.1 → XP_063117947.1  intersectin-2 isoform X5

    UniProtKB/TrEMBL
    A6HAI3

  8. XM_039113109.2 → XP_038969037.1  intersectin-2 isoform X6

    UniProtKB/TrEMBL
    M0R7A6
    Conserved Domains (10) summary
    PTZ00121
    Location:347 → 797
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:780 → 836
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:921 → 972
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:1004 → 1055
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1076 → 1134
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1149 → 1202
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1233 → 1413
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1431 → 1574
    PH_13; Pleckstrin homology domain
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  9. XM_039113110.2 → XP_038969038.1  intersectin-2 isoform X7

    UniProtKB/TrEMBL
    A6HAI6
    Conserved Domains (8) summary
    PTZ00121
    Location:347 → 797
    PTZ00121; MAEBL; Provisional
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:780 → 836
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:921 → 972
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:1004 → 1055
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1076 → 1134
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1149 → 1202
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3

  10. XM_063261878.1 → XP_063117948.1  intersectin-2 isoform X8

    UniProtKB/TrEMBL
    A6HAI6

  11. XM_039113104.2 → XP_038969032.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8K6, M0R7A6
    Conserved Domains (11) summary
    PTZ00121
    Location:347 → 797
    PTZ00121; MAEBL; Provisional
    cd08375
    Location:1574 → 1708
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:780 → 836
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:921 → 972
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:1004 → 1055
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1076 → 1134
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1149 → 1202
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1233 → 1413
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam16652
    Location:1431 → 1574
    PH_13; Pleckstrin homology domain
    cd21577
    Location:106 → 185
    KLF3_N; N-terminal domain of Kruppel-like factor 3
Nucleotide Protein Strain
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