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pon partner of numb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31394, updated on 4-Jan-2025

Summary

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Official Symbol
ponprovided by FlyBase
Official Full Name
partner of numbprovided by FlyBase
Primary source
FLYBASE:FBgn0025739
Locus tag
Dmel_CG3346
See related
AllianceGenome:FB:FBgn0025739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3346; Dmel\CG3346; Pon; PON
Summary
Involved in embryonic heart tube development. Located in cell cortex. Is expressed in imaginal disc and somatic precursor cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See pon in Genome Data Viewer
Location:
4C10-4C10; 1-8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4636318..4639112)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4530351..4533145)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Alstrom syndrome 1b Neighboring gene Alstrom syndrome 1a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Helix loop helix protein 4C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunofluorescent labeling of neural stem cells in the Drosophila optic lobe. Perruchoud B, et al. Methods Mol Biol, 2014. PMID 24048927
  2. Phospho-Pon Binding-Mediated Fine-Tuning of Plk1 Activity. Zhu K, et al. Structure, 2016 Jul 6. PMID 27238966
  3. Abstrakt, a DEAD box protein, regulates Insc levels and asymmetric division of neural and mesodermal progenitors. Irion U, et al. Curr Biol, 2004 Jan 20. PMID 14738736
  4. Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division. Lu B, et al. Mol Cell, 1999 Dec. PMID 10635314
  5. Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages. Homem CC, et al. PLoS One, 2013. PMID 24260257, Free PMC Article

See all (167) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. condensed Numb and Pon complex has roles in phase transition during Drosophila neuroblast asymmetric division
    Title: Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
  2. Pon overexpression alters polar protein distribution is relevant because Pon is often used as a polarity marker in dividing progenitors.
    Title: Overexpression of partner of numb induces asymmetric distribution of the PI4P 5-Kinase Skittles in mitotic sensory organ precursor cells in Drosophila.
  3. Polo directly phosphorylates Partner of Numb (Pon), an adaptor protein for Numb, and this phosphorylation event is important for Pon to localize Numb
    Title: Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.
  4. Numb and Pon rapidly exchange between a cytoplasmic pool and the cell cortex and that preferential recruitment from the cytoplasm is responsible for their asymmetric distribution during mitosis.
    Title: Quantitative analysis of protein dynamics during asymmetric cell division.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in asymmetric neuroblast division TAS
Traceable Author Statement
more info
 PubMed 
involved_in embryonic heart tube development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in basal part of cell TAS
Traceable Author Statement
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
partner of numb
Names
CG3346-PA
pon-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4636318..4639112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080333.3 → NP_525072.2  partner of numb [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525072.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96561, Q9W4I7
    Related
    FBpp0070649
    Conserved Domains (2) summary
    cd16269
    Location:435 → 445
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:358 → 445
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96561 O96561
Q9W4I7 Q9W4I7

Gene LinkOut

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