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HLH4C Helix loop helix protein 4C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31397, updated on 4-Jan-2025

Summary

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Official Symbol
HLH4Cprovided by FlyBase
Official Full Name
Helix loop helix protein 4Cprovided by FlyBase
Primary source
FLYBASE:FBgn0011277
Locus tag
Dmel_CG3052
See related
AllianceGenome:FB:FBgn0011277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLH36; CG3052; Dmel\CG3052; DroNHLH; EG:84H4.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central brain primordium; embryonic pars intercerebralis; ganglia; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. Orthologous to human NHLH1 (nescient helix-loop-helix 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See HLH4C in Genome Data Viewer
Location:
4C10-4C11; 1-8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4645127..4647414, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4539160..4541447, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene partner of numb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene torsin Neighboring gene cap binding protein 80 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two new Drosophila genes related to human hematopoietic and neurogenic transcription factors. Varterasian M, et al. Cell Growth Differ, 1993 Nov. PMID 8297794
  2. The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme. Park D, et al. Mol Cell Biol, 2008 Jan. PMID 17967878, Free PMC Article
  3. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
  4. Transcription factor expression landscape in Drosophila embryonic cell lines. Drewell RA, et al. BMC Genomics, 2024 Mar 23. PMID 38521929, Free PMC Article
  5. The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Ledent V, et al. Genome Res, 2001 May. PMID 11337472, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
helix loop helix protein 4C
Names
CG3052-PA
CG3052-PB
HLH4C-PA
HLH4C-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4645127..4647414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057641.3 → NP_476989.2  helix loop helix protein 4C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476989.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77278, Q9W4I4
    Related
    FBpp0070659, FBtr0070691
    Conserved Domains (1) summary
    cd00083
    Location:108 → 165
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

  2. NM_001272314.1 → NP_001259243.1  helix loop helix protein 4C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH26, O77278
    Conserved Domains (1) summary
    cd00083
    Location:108 → 165
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PH26 M9PH26
Q24353 Q24353
Q9W4I4 Q9W4I4

Gene LinkOut

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