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Pp2C1 Protein phosphatase 2C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31404, updated on 9-Dec-2024

Summary

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Official Symbol
Pp2C1provided by FlyBase
Official Full Name
Protein phosphatase 2Cprovided by FlyBase
Primary source
FLYBASE:FBgn0022768
Locus tag
Dmel_CG2984
See related
AllianceGenome:FB:FBgn0022768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO03040301.132; CG2984; Dmel\CG2984; dpp2c1; PP2C; PP2C1
Summary
Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of gene expression, epigenetic and regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pp2C1 in Genome Data Viewer
Location:
4C12-4C13; 1-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4679988..4686903, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4574021..4580936, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene cap binding protein 80 Neighboring gene uncharacterized protein Neighboring gene fizzy-related Neighboring gene cut up Neighboring gene Pyruvate dehydrogenase E1 alpha subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family. Dick T, et al. Gene, 1997 Oct 15. PMID 9358049
  2. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Jacobs H, et al. Curr Biol, 2002 Aug 20. PMID 12194827
  3. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster. Iranmehr A, et al. Nat Commun, 2021 Feb 12. PMID 33579965, Free PMC Article
  4. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Wharton KA Jr. Dev Biol, 2003 Jan 1. PMID 12490194
  5. A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. Parsons LM, et al. G3 (Bethesda), 2017 Aug 7. PMID 28611255, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein phosphatase 2C
Names
CG2984-PA
CG2984-PB
Pp2C1-PA
Pp2C1-PB
NP_001284867.1
NP_525074.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4679988..4686903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297938.1 → NP_001284867.1  protein phosphatase 2C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77023, Q8T036, Q9W4H8
    Conserved Domains (1) summary
    cd00143
    Location:256 → 567
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. NM_080335.3 → NP_525074.2  protein phosphatase 2C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525074.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77023, Q8T036, Q9W4H8
    Related
    FBpp0070653
    Conserved Domains (1) summary
    cd00143
    Location:256 → 567
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77023 O77023
Q9W4H8 Q9W4H8

Gene LinkOut

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