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CG6927 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31419, updated on 4-Jan-2025

Summary

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Official Symbol
CG6927provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0029733
Locus tag
Dmel_CG6927
See related
AllianceGenome:FB:FBgn0029733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT21430; Dmel\CG6927; Lcch-4D
Summary
Enables pH-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Is expressed in adult optic lobe; antenna; and nurse cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG6927 in Genome Data Viewer
Location:
4D5-4D5; 1-9 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4906900..4908821)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4800933..4802854)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43495 Neighboring gene boilerman Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila. Feingold D, et al. Sci Rep, 2019 May 16. PMID 31097722, Free PMC Article
  2. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
  3. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
  4. Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Gisselmann G, et al. Nat Neurosci, 2002 Jan. PMID 11753412
  5. A novel chloride channel in Drosophila melanogaster is inhibited by protons. Schnizler K, et al. J Biol Chem, 2005 Apr 22. PMID 15713676

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables pH-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6927-PA
glycine-gated chloride channel-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4906900..4908821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_131966.2 → NP_572194.1  uncharacterized protein Dmel_CG6927 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572194.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4G1
    Related
    FBpp0070689
    Conserved Domains (3) summary
    TIGR00860
    Location:3 → 520
    LIC; Cation transporter family protein
    pfam02931
    Location:36 → 259
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:270 → 518
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4G1 Q9W4G1

Gene LinkOut

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