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Plekhh1 pleckstrin homology, MyTH4 and FERM domain containing H1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314262, updated on 27-Nov-2024

Summary

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Official Symbol
Plekhh1provided by RGD
Official Full Name
pleckstrin homology, MyTH4 and FERM domain containing H1provided by RGD
Primary source
RGD:1308362
See related
EnsemblRapid:ENSRNOG00000010650 AllianceGenome:RGD:1308362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytoskeleton. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 89.7), Kidney (RPKM 48.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekhh1 in Genome Data Viewer
Location:
6q24
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103572304..103621729)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (97839288..97888712)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102215424..102264345)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547797 Neighboring gene transmembrane protein 229B Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H Neighboring gene branched chain ketoacid dehydrogenase kinase, pseudogene 1 Neighboring gene arginase 2 Neighboring gene vesicle transport through interaction with t-SNAREs 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family H member 1
Names
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395591.1 → NP_001382520.1  pleckstrin homology domain-containing family H member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HCG0, D4AA54
    Related
    ENSRNOP00000014257.8, ENSRNOT00000014257.9
    Conserved Domains (7) summary
    smart00139
    Location:824 → 978
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:680 → 783
    PH; Pleckstrin homology domain
    smart00295
    Location:991 → 1222
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13282
    Location:573 → 668
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1218 → 1320
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:988 → 1094
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    103572304..103621729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112286.2 → XP_038968214.1  pleckstrin homology domain-containing family H member 1 isoform X1

    UniProtKB/TrEMBL
    A6HCG0, D4AA54
    Conserved Domains (7) summary
    smart00139
    Location:824 → 978
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:680 → 783
    PH; Pleckstrin homology domain
    smart00295
    Location:991 → 1222
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13282
    Location:573 → 668
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1218 → 1320
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:988 → 1094
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_039112284.2 → XP_038968212.1  pleckstrin homology domain-containing family H member 1 isoform X1

    UniProtKB/TrEMBL
    A6HCG0, D4AA54
    Conserved Domains (7) summary
    smart00139
    Location:824 → 978
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:680 → 783
    PH; Pleckstrin homology domain
    smart00295
    Location:991 → 1222
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13282
    Location:573 → 668
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1218 → 1320
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:988 → 1094
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_039112288.2 → XP_038968216.1  pleckstrin homology domain-containing family H member 1 isoform X2

    UniProtKB/TrEMBL
    A6HCG0
    Conserved Domains (7) summary
    smart00139
    Location:824 → 978
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:680 → 783
    PH; Pleckstrin homology domain
    smart00295
    Location:991 → 1222
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13282
    Location:573 → 668
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1218 → 1319
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:988 → 1094
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_039112283.2 → XP_038968211.1  pleckstrin homology domain-containing family H member 1 isoform X1

    UniProtKB/TrEMBL
    A6HCG0, D4AA54
    Conserved Domains (7) summary
    smart00139
    Location:824 → 978
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:680 → 783
    PH; Pleckstrin homology domain
    smart00295
    Location:991 → 1222
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13282
    Location:573 → 668
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1218 → 1320
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:988 → 1094
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. XM_063261930.1 → XP_063118000.1  pleckstrin homology domain-containing family H member 1 isoform X3

  6. XM_039112282.2 → XP_038968210.1  pleckstrin homology domain-containing family H member 1 isoform X1

    UniProtKB/TrEMBL
    A6HCG0, D4AA54
    Conserved Domains (7) summary
    smart00139
    Location:824 → 978
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00233
    Location:680 → 783
    PH; Pleckstrin homology domain
    smart00295
    Location:991 → 1222
    B41; Band 4.1 homologues
    COG1196
    Location:15 → 177
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13282
    Location:573 → 668
    PH1_PLEKHH1_PLEKHH2; Pleckstrin homology (PH) domain containing, family H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain, repeat 1
    cl17171
    Location:1218 → 1320
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:988 → 1094
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. XR_005505523.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108036.2: Suppressed sequence

    Description
    NM_001108036.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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