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Acot3 acyl-CoA thioesterase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314304, updated on 27-Nov-2024

Summary

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Official Symbol
Acot3provided by RGD
Official Full Name
acyl-CoA thioesterase 3provided by RGD
Primary source
RGD:1564089
See related
EnsemblRapid:ENSRNOG00000027960 AllianceGenome:RGD:1564089
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564089
Summary
Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and carboxylic acid metabolic process. Predicted to be located in cytosol and peroxisome. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 132.5), Heart (RPKM 73.7) and 9 other tissues See more
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Genomic context

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See Acot3 in Genome Data Viewer
Location:
6q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109413617..109419840)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103682518..103688735)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107531508..107537446)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23A like 8 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 5 Neighboring gene uncharacterized LOC134479230

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
  2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in saturated monocarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in unsaturated monocarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-CoA thioesterase 3
NP_001101511.1
XP_038968231.1
XP_038968233.1
XP_038968234.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108041.1 → NP_001101511.1  acyl-CoA thioesterase 3

    See identical proteins and their annotated locations for NP_001101511.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A0A8I6A6H9, A6JDS8
    Conserved Domains (3) summary
    pfam04775
    Location:26 → 146
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:212 → 421
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    cl21494
    Location:146 → 262
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109413617..109419840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112306.2 → XP_038968234.1  acyl-CoA thioesterase 3 isoform X3

    Conserved Domains (2) summary
    pfam04775
    Location:25 → 146
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    cl21494
    Location:203 → 221
    Abhydrolase; alpha/beta hydrolases

  2. XM_039112305.2 → XP_038968233.1  acyl-CoA thioesterase 3 isoform X2

    Conserved Domains (2) summary
    pfam04775
    Location:25 → 146
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    cl21494
    Location:212 → 230
    Abhydrolase; alpha/beta hydrolases

  3. XM_039112303.2 → XP_038968231.1  acyl-CoA thioesterase 3 isoform X1

    Related
    ENSRNOP00000086778.2, ENSRNOT00000039048.7
    Conserved Domains (2) summary
    pfam04775
    Location:25 → 146
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    pfam08840
    Location:203 → 412
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
Nucleotide Protein Strain
Heading Accession and Version

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