Ddx41 DEAD-box helicase 41 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ddx41provided by RGD
Full Name: DEAD-box helicase 41provided by RGD
Primary source: RGD:1311758
See related: EnsemblRapid:ENSRNOG00000012771 AllianceGenome:RGD:1311758
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity and RNA helicase activity. Predicted to be involved in several processes, including cGAS/STING signaling pathway; cell population proliferation; and mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to interferon-beta; defense response to virus; and positive regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 127.7), Thymus (RPKM 114.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9108030..9113562)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9102926..9108415)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9631925..9637317)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDX41 is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells. [DDX41]
Title: Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX41

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; probable ATP-dependent RNA helicase DDX41-like

NP_001101516.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108046.2 → NP_001101516.1 probable ATP-dependent RNA helicase DDX41

See identical proteins and their annotated locations for NP_001101516.1

Status: PROVISIONAL

Source sequence(s)

BC166825

UniProtKB/TrEMBL

A0A8I6AB28, A6KAR2, B2RYL8, F7EL80

Related

ENSRNOP00000018114.5, ENSRNOT00000018114.7

Conserved Domains (3) summary

smart00487
Location:196 → 409

DEXDc; DEAD-like helicases superfamily

cd00268
Location:183 → 397

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:418 → 527

Helicase_C; Helicase conserved C-terminal domain