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Wars1 tryptophanyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314442, updated on 27-Nov-2024

Summary

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Official Symbol
Wars1provided by RGD
Official Full Name
tryptophanyl-tRNA synthetase 1provided by RGD
Primary source
RGD:1308278
See related
EnsemblRapid:ENSRNOG00000004359 AllianceGenome:RGD:1308278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Wars
Summary
Predicted to enable several functions, including kinase inhibitor activity; protein homodimerization activity; and tryptophan-tRNA ligase activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; regulation of angiogenesis; and tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 100.1), Brain (RPKM 74.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wars1 in Genome Data Viewer
Location:
6q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133540463..133571645, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127776088..127807273, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132771026..132802262, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479257 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene WD repeat domain 25 Neighboring gene brain-enriched guanylate kinase-associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy. Tsai PC, et al. Brain, 2017 May 1. PMID 28369220, Free PMC Article
  2. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Otani A, et al. Proc Natl Acad Sci U S A, 2002 Jan 8. PMID 11773625, Free PMC Article
  3. A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Wakasugi K, et al. Proc Natl Acad Sci U S A, 2002 Jan 8. PMID 11773626, Free PMC Article
  4. Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases. Wakasugi K. FEBS Lett, 2010 Jan 4. PMID 19941862
  5. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Sajish M, et al. Nat Chem Biol, 2012 Apr 15. PMID 22504299, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables tryptophan-tRNA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tryptophan--tRNA ligase, cytoplasmic
Names
trpRS
tryptophanyl-tRNA synthetase, cytoplasmic
NP_001013188.2
XP_038968331.1
XP_038968332.1
XP_063118081.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013170.2 → NP_001013188.2  tryptophan--tRNA ligase, cytoplasmic

    Status: VALIDATED

    Source sequence(s)
    AY724504
    UniProtKB/TrEMBL
    A6KBI0
    Related
    ENSRNOP00000049063.3, ENSRNOT00000050350.7
    Conserved Domains (3) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    TIGR00233
    Location:158 → 467
    trpS; tryptophanyl-tRNA synthetase
    pfam00458
    Location:16 → 68
    WHEP-TRS; WHEP-TRS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    133540463..133571645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112404.2 → XP_038968332.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A6KBI0, F8WFH8
    Conserved Domains (2) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    cd00936
    Location:16 → 65
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

  2. XM_039112403.2 → XP_038968331.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A6KBI0, F8WFH8
    Conserved Domains (2) summary
    PLN02486
    Location:89 → 470
    PLN02486; aminoacyl-tRNA ligase
    cd00936
    Location:16 → 65
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

  3. XM_063262011.1 → XP_063118081.1  tryptophan--tRNA ligase, cytoplasmic isoform X2

    Related
    ENSRNOP00000073702.1, ENSRNOT00000080163.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7B0.2 GenPept UniProtKB/Swiss-Prot:Q6P7B0

Gene LinkOut

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