Plppr3 phospholipid phosphatase related 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plppr3provided by RGD
Official Full Name: phospholipid phosphatase related 3provided by RGD
Primary source: RGD:727823
See related: EnsemblRapid:ENSRNOG00000027940 AllianceGenome:RGD:727823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lppr3; Prg-2
Summary: Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human PLPPR3 (phospholipid phosphatase related 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 57.8), Kidney (RPKM 11.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10481624..10493059)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9831162..9842434)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12652555..12663825)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Ptb (e-PCR), detects polymorphism
- UniSTS:144286

RH128371 (e-PCR)
- UniSTS:211679

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phospholipid phosphatase-related protein type 3

Names: inactive phospholipid phosphatase PLPPR3; lipid phosphate phosphatase-related protein type 3; plasticity-related gene 2 protein; plasticity-related protein PRG-2; plasticity-related protein PRG-2-like

NP_853665.2

EC 3.1.3.4

XP_063119480.1

EC 3.1.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181634.3 → NP_853665.2 phospholipid phosphatase-related protein type 3

See identical proteins and their annotated locations for NP_853665.2

Status: VALIDATED

Source sequence(s)

BC167750, JAXUCZ010000007

UniProtKB/Swiss-Prot

Q7TMB0

UniProtKB/TrEMBL

B3DM92, F1LMM6

Related

ENSRNOP00000029601.4, ENSRNOT00000031315.8

Conserved Domains (1) summary

cd03384
Location:127 → 276

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...