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Sbno2 strawberry notch homolog 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314619, updated on 2-Nov-2024

Summary

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Official Symbol
Sbno2provided by RGD
Official Full Name
strawberry notch homolog 2provided by RGD
Primary source
RGD:1307194
See related
EnsemblRapid:ENSRNOG00000013987 AllianceGenome:RGD:1307194
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Stno; RGD1307194
Summary
Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; macrophage activation involved in immune response; and regulation of DNA-templated transcription. Predicted to act upstream of or within bone mineralization; bone trabecula morphogenesis; and osteoclast fusion. Predicted to be active in nucleus. Orthologous to human SBNO2 (strawberry notch homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 54.0), Adrenal (RPKM 51.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sbno2 in Genome Data Viewer
Location:
7q11
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10256221..10300175)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9605572..9649529)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12471805..12515700)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene serine/threonine kinase 11 Neighboring gene uncharacterized LOC134479811 Neighboring gene uncharacterized LOC134479812 Neighboring gene glutathione peroxidase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. Grill M, et al. Glia, 2015 Oct. PMID 25903009, Free PMC Article
  2. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. El Kasmi KC, et al. J Immunol, 2007 Dec 1. PMID 18025162
  3. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. Maruyama K, et al. J Exp Med, 2013 Sep 23. PMID 23980096, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone trabecula morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-11 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-6 IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interleukin-6 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in macrophage activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multinuclear osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoclast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein strawberry notch homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108068.1 → NP_001101538.1  protein strawberry notch homolog 2

    See identical proteins and their annotated locations for NP_001101538.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474029
    UniProtKB/TrEMBL
    A0A8I6A186, A6K8R8, A6K8R9, D3ZDU8
    Related
    ENSRNOP00000062533.2, ENSRNOT00000068197.5
    Conserved Domains (2) summary
    pfam13871
    Location:659 → 937
    Helicase_C_4; C-terminal domain on Strawberry notch homologue
    pfam13872
    Location:145 → 433
    AAA_34; P-loop containing NTP hydrolase pore-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10256221..10300175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594814.3 → XP_017450303.1  protein strawberry notch homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZZ8, A0A8I6A186, A6K8R6, A6K8R9
    Related
    ENSRNOP00000071247.1, ENSRNOT00000077146.3
    Conserved Domains (2) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homologue
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1

  2. XM_006240908.5 → XP_006240970.1  protein strawberry notch homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006240970.1

    UniProtKB/TrEMBL
    A0A0G2JZZ8, A0A8I6A186, A6K8R6, A6K8R9
    Conserved Domains (2) summary
    pfam13871
    Location:726 → 1004
    Helicase_C_4; C-terminal domain on Strawberry notch homologue
    pfam13872
    Location:212 → 500
    AAA_34; P-loop containing NTP hydrolase pore-1

  3. XM_008765095.4 → XP_008763317.1  protein strawberry notch homolog 2 isoform X2

    See identical proteins and their annotated locations for XP_008763317.1

    UniProtKB/TrEMBL
    A0A8I6A186, A6K8R8, A6K8R9, D3ZDU8
    Related
    ENSRNOP00000084971.1, ENSRNOT00000099606.2
    Conserved Domains (2) summary
    pfam13871
    Location:659 → 937
    Helicase_C_4; C-terminal domain on Strawberry notch homologue
    pfam13872
    Location:145 → 433
    AAA_34; P-loop containing NTP hydrolase pore-1
Nucleotide Protein Strain
Heading Accession and Version

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