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frma fra mauro [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31464, updated on 9-Dec-2024

Summary

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Official Symbol
frmaprovided by FlyBase
Official Full Name
fra mauroprovided by FlyBase
Primary source
FLYBASE:FBgn0029769
Locus tag
Dmel_CG3239
See related
AllianceGenome:FB:FBgn0029769
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH09377; CG3239; Dmel\CG3239; Nepl1
Summary
Involved in negative regulation of female receptivity, post-mating. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See frma in Genome Data Viewer
Location:
5A1-5A1; 1-12 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5493014..5496052, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5387047..5390085, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44471 Neighboring gene uncharacterized protein Neighboring gene Sex peptide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of the sex peptide network in Drosophila. McGeary MK, et al. J Evol Biol, 2020 May. PMID 31991034
  2. Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure. Tu Q, et al. Chemosphere, 2023 Jul. PMID 37080472
  3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
  4. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812
  5. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of female receptivity, post-mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fra mauro
Names
CG3239-PF
CG3239-PG
Dmel_CG3239
Neprilysin-like 1
frma-PF
frma-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5493014..5496052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167038.2 → NP_726999.2  fra mauro, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726999.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3N8, Q8IRR7, Q95TX8, Q9W4B8
    Conserved Domains (1) summary
    cl14813
    Location:25 → 601
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  2. NM_131998.3 → NP_572226.2  fra mauro, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572226.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3N8, Q8IRR7, Q95TX8, Q9W4B8
    Conserved Domains (1) summary
    cl14813
    Location:25 → 601
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3N8 Q7K3N8
Q9W4B8 Q9W4B8

Gene LinkOut

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