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Celf5 CUGBP, Elav-like family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314647, updated on 4-Jan-2025

Summary

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Official Symbol
Celf5provided by RGD
Official Full Name
CUGBP, Elav-like family member 5provided by RGD
Primary source
RGD:1565016
See related
EnsemblRapid:ENSRNOG00000004695 AllianceGenome:RGD:1565016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brunol5; RGD1565016
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF5 (CUGBP Elav-like family member 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 55.2) and Testes (RPKM 3.2) See more
Orthologs
human mouse all
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Genomic context

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See Celf5 in Genome Data Viewer
Location:
7q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8876551..8901078)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8225787..8250322)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11095449..11119941)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene nicalin Neighboring gene nuclear factor I/C Neighboring gene uncharacterized LOC120093769 Neighboring gene small integral membrane protein 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Ladd AN, et al. Mol Cell Biol, 2001 Feb. PMID 11158314, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CUGBP Elav-like family member 5
Names
CUG-BP- and ETR-3-like factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135603.3 → NP_001129075.1  CUGBP Elav-like family member 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000103307.1, ENSRNOT00000161972.1
    Conserved Domains (3) summary
    TIGR01628
    Location:9 → 356
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:95 → 175
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8876551..8901078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240942.5 → XP_006241004.2  CUGBP Elav-like family member 5 isoform X2

    Conserved Domains (4) summary
    TIGR01628
    Location:9 → 357
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:356 → 434
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94 → 174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  2. XM_039079023.2 → XP_038934951.1  CUGBP Elav-like family member 5 isoform X1

    UniProtKB/TrEMBL
    D4A8V0
    Related
    ENSRNOP00000057932.3, ENSRNOT00000061219.4
    Conserved Domains (4) summary
    TIGR01628
    Location:9 → 358
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12639
    Location:357 → 435
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:95 → 175
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  3. XM_017594819.3 → XP_017450308.1  CUGBP Elav-like family member 5 isoform X3

    Conserved Domains (3) summary
    TIGR01628
    Location:9 → 355
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12632
    Location:2 → 88
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94 → 174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  4. XM_008765105.4 → XP_008763327.1  CUGBP Elav-like family member 5 isoform X8

    Conserved Domains (3) summary
    cd12639
    Location:281 → 359
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:5 → 361
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:19 → 99
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  5. XM_063263433.1 → XP_063119503.1  CUGBP Elav-like family member 5 isoform X13

  6. XM_063263431.1 → XP_063119501.1  CUGBP Elav-like family member 5 isoform X12

    UniProtKB/TrEMBL
    A6K877

  7. XM_063263432.1 → XP_063119502.1  CUGBP Elav-like family member 5 isoform X12

    UniProtKB/TrEMBL
    A6K877

  8. XM_039079024.2 → XP_038934952.1  CUGBP Elav-like family member 5 isoform X4

    Conserved Domains (3) summary
    cd12639
    Location:315 → 393
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:39 → 395
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:53 → 133
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  9. XM_039079025.2 → XP_038934953.1  CUGBP Elav-like family member 5 isoform X5

    Conserved Domains (3) summary
    cd12639
    Location:314 → 392
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:42 → 394
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:52 → 132
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  10. XM_039079026.2 → XP_038934954.1  CUGBP Elav-like family member 5 isoform X9

    Conserved Domains (2) summary
    TIGR01628
    Location:31 → 313
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:52 → 132
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  11. XM_063263430.1 → XP_063119500.1  CUGBP Elav-like family member 5 isoform X10

  12. XM_008765104.4 → XP_008763326.1  CUGBP Elav-like family member 5 isoform X6

    Conserved Domains (3) summary
    cd12635
    Location:25 → 105
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:287 → 365
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:11 → 367
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  13. XM_039079027.2 → XP_038934955.1  CUGBP Elav-like family member 5 isoform X7

    Conserved Domains (3) summary
    cd12639
    Location:286 → 364
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:14 → 366
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:24 → 104
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

  14. XM_039079028.2 → XP_038934956.1  CUGBP Elav-like family member 5 isoform X11

    Conserved Domains (2) summary
    TIGR01628
    Location:27 → 285
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12635
    Location:24 → 104
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
Nucleotide Protein Strain
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