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Ncln nicalin [ Rattus norvegicus (Norway rat) ]

Gene ID: 314648, updated on 4-Jan-2025

Summary

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Official Symbol
Nclnprovided by RGD
Official Full Name
nicalinprovided by RGD
Primary source
RGD:1309355
See related
EnsemblRapid:ENSRNOG00000004793 AllianceGenome:RGD:1309355
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309355
Summary
Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including multi-pass transmembrane protein insertion into ER membrane; protein stabilization; and regulation of protein complex stability. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 165.8), Kidney (RPKM 148.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncln in Genome Data Viewer
Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8862324..8872699)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8211978..8221938)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11081544..11091583)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 15 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene nuclear factor I/C Neighboring gene uncharacterized LOC120093769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. Dettmer U, et al. J Biol Chem, 2010 Aug 20. PMID 20538592, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in multi-pass transmembrane protein insertion into ER membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in multi-pass transmembrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in multi-pass transmembrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein complex stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of multi-pass translocon complex IEA
Inferred from Electronic Annotation
more info
  
part_of multi-pass translocon complex ISO
Inferred from Sequence Orthology
more info
  
part_of multi-pass translocon complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BOS complex subunit NCLN
Names
nicalin homolog
nicastrin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014082.1 → NP_001014104.1  BOS complex subunit NCLN precursor

    See identical proteins and their annotated locations for NP_001014104.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083785
    UniProtKB/Swiss-Prot
    Q5XIA1
    UniProtKB/TrEMBL
    A6K875, A6K876
    Related
    ENSRNOP00000077163.2, ENSRNOT00000094550.2
    Conserved Domains (1) summary
    cd03882
    Location:130 → 429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8862324..8872699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240943.3 → XP_006241005.1  BOS complex subunit NCLN isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHD9, A6K876
    Conserved Domains (1) summary
    cd03882
    Location:130 → 429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIA1.1 GenPept UniProtKB/Swiss-Prot:Q5XIA1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
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