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Abtb3 ankyrin repeat and BTB domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314675, updated on 27-Nov-2024

Summary

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Official Symbol
Abtb3provided by RGD
Official Full Name
ankyrin repeat and BTB domain containing 3provided by RGD
Primary source
RGD:1308647
See related
EnsemblRapid:ENSRNOG00000005758 AllianceGenome:RGD:1308647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Btbd11
Summary
Predicted to enable PDZ domain binding activity. Predicted to act upstream of or within exploration behavior; glutamatergic synaptic transmission; and protein stabilization. Predicted to be located in glutamatergic synapse. Orthologous to human ABTB3 (ankyrin repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 39.6), Adrenal (RPKM 37.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Abtb3 in Genome Data Viewer
Location:
7q13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (19922883..20199740, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (18035151..18310718, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (24041194..24314418, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PR/SET domain 4 Neighboring gene PWP1 homolog, endonuclein Neighboring gene Y box binding protein 1, pseudogene 21 Neighboring gene uncharacterized LOC134479646 Neighboring gene sialic acid synthase-like Neighboring gene cryptochrome circadian regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within exploration behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and BTB/POZ domain-containing protein BTBD11; ankyrin repeat and BTB/POZ domain-containing protein 3
Names
BTB (POZ) domain containing 11
BTB domain containing 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432632.1 → NP_001419561.1  ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D4AC89

  2. NM_001432634.1 → NP_001419563.1  ankyrin repeat and BTB/POZ domain-containing protein BTBD11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AJE8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    19922883..20199740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264584.1 → XP_063120654.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X4

  2. XM_063264583.1 → XP_063120653.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    D3Z9Y5
    Related
    ENSRNOP00000008596.6, ENSRNOT00000008596.9

  3. XM_039080070.2 → XP_038935998.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X3

    Conserved Domains (5) summary
    COG5262
    Location:192 → 248
    HTA1; Histone H2A [Chromatin structure and dynamics]
    sd00045
    Location:615 → 656
    ANK; ANK repeat [structural motif]
    cd18351
    Location:789 → 919
    BTB_POZ_BTBD11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
    cd18527
    Location:912 → 994
    BACK_BTBD11; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
    pfam12796
    Location:589 → 685
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039080069.2 → XP_038935997.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X1

    Related
    ENSRNOP00000045550.6, ENSRNOT00000044331.8
    Conserved Domains (5) summary
    COG5262
    Location:192 → 248
    HTA1; Histone H2A [Chromatin structure and dynamics]
    sd00045
    Location:615 → 656
    ANK; ANK repeat [structural motif]
    cd18351
    Location:908 → 1038
    BTB_POZ_BTBD11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
    cd18527
    Location:1031 → 1113
    BACK_BTBD11; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
    pfam12796
    Location:617 → 723
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_063264587.1 → XP_063120657.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X7

  6. XM_063264585.1 → XP_063120655.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X5

  7. XM_063264588.1 → XP_063120658.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X8

  8. XM_039080071.2 → XP_038935999.1  ankyrin repeat and BTB/POZ domain-containing protein 3 isoform X6

    Conserved Domains (5) summary
    sd00045
    Location:134 → 175
    ANK; ANK repeat [structural motif]
    cd18351
    Location:427 → 557
    BTB_POZ_BTBD11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
    cd18527
    Location:550 → 632
    BACK_BTBD11; BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11)
    pfam13637
    Location:218 → 279
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:136 → 242
    Ank_2; Ankyrin repeats (3 copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108078.1: Suppressed sequence

    Description
    NM_001108078.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: BTBD11 (GeneID:121551).
Nucleotide Protein Strain
Heading Accession and Version

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