RhoGAP5A Rho GTPase activating protein at 5A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RhoGAP5Aprovided by FlyBase
Official Full Name: Rho GTPase activating protein at 5Aprovided by FlyBase
Primary source: FLYBASE:FBgn0029778
Locus tag: Dmel_CG3208
See related: AllianceGenome:FB:FBgn0029778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3208; Dmel\CG3208; RhoGAP
Summary: Predicted to enable GTPase activator activity. Involved in several processes, including imaginal disc-derived leg morphogenesis; negative regulation of adherens junction organization; and negative regulation of signal transduction. Is expressed in tarsal segment. Human ortholog(s) of this gene implicated in Duane retraction syndrome. Orthologous to several human genes including CHN1 (chimerin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5A8-5A8; 1-12 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5616572..5618806, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5510605..5512839, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results reveal a role for chimaerin in the regulation of ERK signaling and cell-cell adhesion and have implications for its participation in epithelial development and tumor progression.
Title: Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Rho GTPase activating protein at 5A

Names: CG3208-PA; CG3208-PB; RhoGAP5A-PA; RhoGAP5A-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5616572..5618806 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_132007.4 → NP_572235.1 Rho GTPase activating protein at 5A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572235.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961S1

Related

FBpp0070750

Conserved Domains (3) summary

cd10352
Location:75 → 166

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

pfam00130
Location:242 → 294

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:302 → 440

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_167040.4 → NP_727007.1 Rho GTPase activating protein at 5A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727007.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W4A9

Related

FBpp0070751

Conserved Domains (3) summary

cd10352
Location:75 → 166

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:302 → 491

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:242 → 294

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)