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Usp44 ubiquitin specific peptidase 44 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314746, updated on 4-Jan-2025

Summary

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Official Symbol
Usp44provided by RGD
Official Full Name
ubiquitin specific peptidase 44provided by RGD
Primary source
RGD:1308216
See related
EnsemblRapid:ENSRNOG00000005637 AllianceGenome:RGD:1308216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including antiviral innate immune response; negative regulation of ubiquitin protein ligase activity; and regulation of mitotic metaphase/anaphase transition. Predicted to be active in cytoplasm and nucleus. Orthologous to human USP44 (ubiquitin specific peptidase 44). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 143.3), Spleen (RPKM 19.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Usp44 in Genome Data Viewer
Location:
7q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30251142..30301185)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28364169..28412039)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34714293..34759352)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479662 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 Neighboring gene methionyl aminopeptidase 2 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene uncharacterized LOC120093556 Neighboring gene microRNA 331

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. Suresh B, et al. Cell Biol Int, 2010 Aug. PMID 20402667
  2. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. Zhang Y, et al. PLoS One, 2011. PMID 21853124, Free PMC Article
  3. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. Zhang Y, et al. J Clin Invest, 2012 Dec. PMID 23187126, Free PMC Article
  4. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Stegmeier F, et al. Nature, 2007 Apr 19. PMID 17443180
  5. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI, et al. Int J Biochem Cell Biol, 2014 May. PMID 24647359

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 44
Names
ubiquitin specific protease 44
ubiquitin thiolesterase 44
NP_001381000.1
XP_038934982.1
XP_038934983.1
XP_038934988.1
XP_038934989.1
XP_038934991.1
XP_038934996.1
XP_063119514.1
XP_063119515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394071.2 → NP_001381000.1  ubiquitin carboxyl-terminal hydrolase 44

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6A942
    Conserved Domains (2) summary
    pfam00443
    Location:271 → 676
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RNA

  1. NR_172074.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    30251142..30301185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079054.2 → XP_038934982.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    UniProtKB/TrEMBL
    D4A251
    Related
    ENSRNOP00000007465.6, ENSRNOT00000007465.7
    Conserved Domains (2) summary
    pfam00443
    Location:288 → 693
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:43 → 104
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. XM_039079061.2 → XP_038934989.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    UniProtKB/TrEMBL
    D4A251
    Conserved Domains (2) summary
    pfam00443
    Location:288 → 693
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:43 → 104
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  3. XM_063263445.1 → XP_063119515.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X3

    UniProtKB/TrEMBL
    A6IFZ4

  4. XM_063263444.1 → XP_063119514.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    UniProtKB/TrEMBL
    D4A251

  5. XM_039079063.2 → XP_038934991.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A942
    Conserved Domains (2) summary
    pfam00443
    Location:271 → 676
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  6. XM_039079055.2 → XP_038934983.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    UniProtKB/TrEMBL
    D4A251
    Related
    ENSRNOP00000089591.2, ENSRNOT00000105243.2
    Conserved Domains (2) summary
    pfam00443
    Location:288 → 693
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:43 → 104
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  7. XM_039079060.2 → XP_038934988.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    UniProtKB/TrEMBL
    D4A251
    Conserved Domains (2) summary
    pfam00443
    Location:288 → 693
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:43 → 104
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  8. XM_039079068.2 → XP_038934996.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A942
    Related
    ENSRNOP00000107316.1, ENSRNOT00000124420.1
    Conserved Domains (2) summary
    pfam00443
    Location:271 → 676
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:26 → 87
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
Nucleotide Protein Strain
Heading Accession and Version

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