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Pop1 POP1 ribonuclease P/MRP subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31475, updated on 9-Dec-2024

Summary

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Official Symbol
Pop1provided by FlyBase
Official Full Name
POP1 ribonuclease P/MRP subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0026702
Locus tag
Dmel_CG32763
See related
AllianceGenome:FB:FBgn0026702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD21623; CG32763; CG4129; Dmel\CG32763; l(1)G0045; l(1)G0312
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in rRNA processing and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Is expressed in organism. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Orthologous to human POP1 (POP1 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pop1 in Genome Data Viewer
Location:
5A8-5A8; 1-12 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5622648..5625493)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5516681..5519526)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 5A Neighboring gene Myosin light chain cytoplasmic Neighboring gene mir-3645 stem loop Neighboring gene Otopetrin-like a Neighboring gene Otopetrin-like c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia. Glazov EA, et al. PLoS Genet, 2011 Mar. PMID 21455487, Free PMC Article
  2. Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits. Palsule G, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287870, Free PMC Article
  3. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad MA, et al. Nucleic Acids Res, 2006. PMID 16998185, Free PMC Article
  4. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article
  5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribonuclease P RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA 5'-leader removal IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA 5'-leader removal ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleolar ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
POP1 ribonuclease P/MRP subunit
Names
CG32763-PA
Pop1-PA
lethal (1) G0045

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5622648..5625493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132008.4 → NP_572236.3  POP1 ribonuclease P/MRP subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572236.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVW2, Q9W4A7, Q9XZ20
    Related
    FBpp0070748
    Conserved Domains (2) summary
    pfam06978
    Location:33 → 178
    POP1; Ribonucleases P/MRP protein subunit POP1
    pfam08170
    Location:514 → 600
    POPLD; POPLD (NUC188) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KVW2 Q7KVW2
Q9W4A7 Q9W4A7

Gene LinkOut

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