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Tmcc3 transmembrane and coiled-coil domain family 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314751, updated on 2-Nov-2024

Summary

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Official Symbol
Tmcc3provided by RGD
Official Full Name
transmembrane and coiled-coil domain family 3provided by RGD
Primary source
RGD:1307241
See related
EnsemblRapid:ENSRNOG00000007713 AllianceGenome:RGD:1307241
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307241
Summary
Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Orthologous to human TMCC3 (transmembrane and coiled-coil domain family 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 73.7), Muscle (RPKM 63.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmcc3 in Genome Data Viewer
Location:
7q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30781452..31058888)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28893972..29171935)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35266953..35543770)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene U4 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene uncharacterized LOC102554269 Neighboring gene uncharacterized LOC134479860 Neighboring gene 60S ribosomal protein L31-like Neighboring gene uncharacterized LOC120093558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and characterization of transmembrane and coiled-coil domain family 3. Sohn WJ, et al. BMB Rep, 2016 Nov. PMID 27697108, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domain protein 3
Names
transmembrane and coiled coil domains 3
transmembrane and coiled-coil domains protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108084.2 → NP_001101554.1  transmembrane and coiled-coil domain protein 3

    See identical proteins and their annotated locations for NP_001101554.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2K8Y7, A6IG18, D3ZLE2
    Related
    ENSRNOP00000010316.4, ENSRNOT00000010316.7
    Conserved Domains (1) summary
    pfam10267
    Location:69 → 463
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    30781452..31058888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263459.1 → XP_063119529.1  transmembrane and coiled-coil domain protein 3 isoform X4

    UniProtKB/TrEMBL
    A6IG20

  2. XM_039079077.2 → XP_038935005.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5Y957, A6IG16
    Related
    ENSRNOP00000076849.1, ENSRNOT00000094886.2
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 446
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  3. XM_039079074.2 → XP_038935002.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5Y957, A6IG16
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 446
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  4. XM_063263453.1 → XP_063119523.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  5. XM_017594836.3 → XP_017450325.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5Y957, A6IG16
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 446
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  6. XM_063263452.1 → XP_063119522.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  7. XM_063263450.1 → XP_063119520.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  8. XM_063263451.1 → XP_063119521.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  9. XM_063263458.1 → XP_063119528.1  transmembrane and coiled-coil domain protein 3 isoform X4

    UniProtKB/TrEMBL
    A6IG20
    Related
    ENSRNOP00000074786.2, ENSRNOT00000080291.3

  10. XM_063263456.1 → XP_063119526.1  transmembrane and coiled-coil domain protein 3 isoform X4

    UniProtKB/TrEMBL
    A6IG20

  11. XM_063263449.1 → XP_063119519.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  12. XM_039079073.2 → XP_038935001.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5Y957, A6IG16
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 446
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  13. XM_063263447.1 → XP_063119517.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  14. XM_063263448.1 → XP_063119518.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y957, A6IG16

  15. XM_017594840.3 → XP_017450329.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5Y957, A6IG16
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 446
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  16. XM_039079076.2 → XP_038935004.1  transmembrane and coiled-coil domain protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5Y957, A6IG16
    Conserved Domains (1) summary
    pfam10267
    Location:48 → 446
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  17. XM_039079081.2 → XP_038935009.1  transmembrane and coiled-coil domain protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A6IG20
    Conserved Domains (1) summary
    pfam10267
    Location:34 → 432
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  18. XM_039079079.2 → XP_038935007.1  transmembrane and coiled-coil domain protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5ZPM9
    Conserved Domains (1) summary
    pfam10267
    Location:40 → 438
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  19. XM_063263455.1 → XP_063119525.1  transmembrane and coiled-coil domain protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZPM9
    Related
    ENSRNOP00000079968.1, ENSRNOT00000095728.2

  20. XM_063263454.1 → XP_063119524.1  transmembrane and coiled-coil domain protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZPM9

  21. XM_063263446.1 → XP_063119516.1  transmembrane and coiled-coil domain protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT53
    Related
    ENSRNOP00000081540.1, ENSRNOT00000102476.2

  22. XM_006241261.5 → XP_006241323.1  transmembrane and coiled-coil domain protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K8Y7, A0A8I5ZPM9
    Conserved Domains (1) summary
    pfam10267
    Location:40 → 438
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  23. XM_063263457.1 → XP_063119527.1  transmembrane and coiled-coil domain protein 3 isoform X4

    UniProtKB/TrEMBL
    A6IG20
Nucleotide Protein Strain
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